Glucose 1-dehydrogenase (NAD+)
In enzymology, a glucose 1-dehydrogenase (NAD+) (EC 1.1.1.118) is an enzyme that catalyzes the chemical reaction
- D-glucose + NAD+ D-glucono-1,5-lactone + NADH + H+
| glucose 1-dehydrogenase (NAD+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.118 | ||||||||
| CAS number | 37250-49-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are D-glucose and NAD+, whereas its 3 products are D-glucono-1,5-lactone, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glucose:NAD+ 1-oxidoreductase. Other names in common use include D-glucose:NAD+ oxidoreductase, D-aldohexose dehydrogenase, and glucose 1-dehydrogenase (NAD+).
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DTD, 2DTE, and 2DTX.
gollark: That is... entirely normal and consistent?
gollark: Well, ++experimental_qa uses a 44MB neural network running very slowly on my server's few-hundred-GFLOPS CPU. According to GTech™ bee scientists, human brains are at least 10PB and require/contain 10PFLOPS of computing power.
gollark: ...
gollark: ++experimental_qa bike Who has the bike wheel?
gollark: Fascinating.
References
- Hu AS, Cline AL (November 1964). "The regulation of some sugar dehydrogenases in a pseudomonad". Biochimica et Biophysica Acta (BBA) - General Subjects. 93 (2): 237–45. doi:10.1016/0304-4165(64)90371-x. PMID 14251301.
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