Gluconate 2-dehydrogenase (acceptor)
In enzymology, a gluconate 2-dehydrogenase (acceptor) (EC 1.1.99.3) is an enzyme that catalyzes the chemical reaction
- D-gluconate + acceptor 2-dehydro-D-gluconate + reduced acceptor
| Gluconate 2-dehydrogenase (acceptor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.99.3 | ||||||||
| CAS number | 9028-81-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are D-gluconate and acceptor, whereas its two products are 2-dehydro-D-gluconate and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-gluconate:acceptor 2-oxidoreductase. Other names in common use include gluconate oxidase, gluconate dehydrogenase, gluconic dehydrogenase, D-gluconate dehydrogenase, gluconic acid dehydrogenase, 2-ketogluconate reductase, D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding, and D-gluconate:(acceptor) 2-oxidoreductase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, FAD.
References
- Matsushita K, Shinagawa E, Ameyama M (1982). "D-Gluconate dehydrogenase from bacteria, 2-keto-D-gluconate-yielding, membrane-bound". Methods Enzymol. 89 Pt. D: 187–93. PMID 6815420.
- Ramakrishnan T; Campbell JJR (1955). "Gluconic dehydrogenase of Pseudomonas aeruginosa". Biochim. Biophys. Acta. 17 (1): 122–127. doi:10.1016/0006-3002(55)90326-7. PMID 13239635.