Gingipain K

Gingipain K (EC 3.4.22.47, Lys-gingipain, PrtP proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Endopeptidase with strict specificity for lysyl bonds
Gingipain K
Identifiers
EC number3.4.22.47
CAS number159745-69-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Activity of this enzyme is stimulated by glycine.

References

  1. Pike R, McGraw W, Potempa J, Travis J (January 1994). "Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins". The Journal of Biological Chemistry. 269 (1): 406–11. PMID 8276827.
  2. Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B (December 2002). "Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor". Infection and Immunity. 70 (12): 6968–75. doi:10.1128/iai.70.12.6968-6975.2002. PMC 132948. PMID 12438376.
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