Formiminoglutamic acid

Formiminoglutamic acid (FIGLU) is an intermediate in the catabolism of L-histidine to L-glutamic acid and marker for intracellular levels of folate. The FIGLU test is used to identify deficiencies of vitamin B₁₂ or folate and is also found in liver disease.[1][2] It is elevated with folate trapping, where it is accompanied by decreased methylmalonic acid, increased folate and a decrease in homocysteine.[3]

Formiminoglutamic acid

Names
IUPAC name N-(aminomethylidene)-L-glutamic acid
Other names FIGLU
Identifiers
CAS Number	816-90-0^Y
3D model (JSmol)	Interactive image
ChemSpider	388370^N
ECHA InfoCard	100.011.308
MeSH	Formiminoglutamic+acid
PubChem CID	909
UNII	YV703N7VOG^Y
SMILES C(CC(=O)O)C(C(=O)O)N=CN
Properties
Chemical formula	C6H10N2O4
Molar mass	174.156 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

See also

• Formiminotransferase cyclodeaminase
• Glutamate-1-semialdehyde
• Glutamic acid
• Imidazol-4-one-5-propionic acid

References

1. Lascelles, P. T.; Donaldson, D. (1989). "Formiminoglutamic Acid (FIGLU) Test". Diagnostic Function Tests in Chemical Pathology. pp. 59–60. doi:10.1007/978-94-009-1846-7_31. ISBN 978-0-7462-0107-7.
2. FIGLU+Test at the US National Library of Medicine Medical Subject Headings (MeSH)
3. Scott, JohnM.; Weir, DonaldG. (15 August 1981). "THE METHYL FOLATE TRAP: A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia". The Lancet. 318 (8242): 337–340. doi:10.1016/S0140-6736(81)90650-4. ISSN 0140-6736.