Flavivirin
Flavivirin (EC 3.4.21.91, Yellow fever virus (flavivirus) protease, NS2B-3 proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Selective hydrolysis of -Xaa-Xaa-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala
| Flavivirin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.91 | ||||||||
| CAS number | 154215-26-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in classical flaviviruses (yellow fever, dengue fever).
References
- Chambers TJ, Hahn CS, Galler R, Rice CM (1990). "Flavivirus genome organization, expression, and replication". Annual Review of Microbiology. 44: 649–88. doi:10.1146/annurev.mi.44.100190.003245. PMID 2174669.
- Cahour A, Falgout B, Lai CJ (March 1992). "Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease". Journal of Virology. 66 (3): 1535–42. PMC 240879. PMID 1531368.
- Lin C, Amberg SM, Chambers TJ, Rice CM (April 1993). "Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site". Journal of Virology. 67 (4): 2327–35. PMC 240389. PMID 8445732.
External links
- Flavivirin at the US National Library of Medicine Medical Subject Headings (MeSH)
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