KLK8

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.[5][6][7][8][9]

KLK8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NPM
Identifiers
Aliases	KLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDs	OMIM: 605644 MGI: 1343327 HomoloGene: 21410 GeneCards: KLK8
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 50,996,007 bp[1] End 51,002,711 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,797,577 bp[2] End 43,803,826 bp[2]
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • GO:0001948 protein binding • hydrolase activity Cellular component • cytoplasm • extracellular region • extracellular • serine protease inhibitor complex • secretory granule Biological process • synapse organization • keratinocyte proliferation • negative regulation of axon regeneration • neuron projection morphogenesis • cell death • memory • response to wounding • negative regulation of myelination • regulation of synapse organization • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11202	259277
Ensembl	ENSG00000129455	ENSMUSG00000064023
UniProt	O60259	Q61955
RefSeq (mRNA)	NM_001281431 NM_007196 NM_144505 NM_144506 NM_144507	NM_008940 NM_001324398
RefSeq (protein)	NP_001268360 NP_009127 NP_653088 NP_653089 NP_653090	NP_001311327 NP_032966
Location (UCSC)	Chr 19: 51 – 51 Mb	Chr 7: 43.8 – 43.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000129455 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000064023 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (May 1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur J Biochem. 260 (3): 627–34. doi:10.1046/j.1432-1327.1999.00213.x. PMID 10102990.
6. Yoshida S, Taniguchi M, Hirata A, Shiosaka S (Aug 1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene. 213 (1–2): 9–16. doi:10.1016/S0378-1119(98)00232-7. PMID 9714609.
7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
8. Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
9. "Entrez Gene: KLK8 kallikrein-related peptidase 8".

Further reading

• Underwood LJ, Tanimoto H, Wang Y, et al. (1999). "Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma". Cancer Res. 59 (17): 4435–9. PMID 10485494.
• Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.
• Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
• Magklara A, Scorilas A, Katsaros D, et al. (2001). "The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer". Clin. Cancer Res. 7 (4): 806–11. PMID 11309326.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Cané S, Bignotti E, Bellone S, et al. (2004). "The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer". Am. J. Obstet. Gynecol. 190 (1): 60–6. doi:10.1016/j.ajog.2003.07.020. PMID 14749636.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Shigemasa K, Tian X, Gu L, et al. (2004). "Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer". Oncol. Rep. 11 (6): 1153–9. doi:10.3892/or.11.6.1153. PMID 15138549.
• Li Y, Qian YP, Yu XJ, et al. (2005). "Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory". Mol. Biol. Evol. 21 (11): 2111–5. doi:10.1093/molbev/msh220. PMID 15282331.
• Rajapakse S, Ogiwara K, Takano N, et al. (2006). "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Lett. 579 (30): 6879–84. doi:10.1016/j.febslet.2005.11.039. hdl:2115/985. PMID 16337200.
• Kishi T, Cloutier SM, Kündig C, et al. (2006). "Activation and enzymatic characterization of recombinant human kallikrein 8" (PDF). Biol. Chem. 387 (6): 723–31. doi:10.1515/BC.2006.091. PMID 16800733.
• Sher YP, Chou CC, Chou RH, et al. (2007). "Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness". Cancer Res. 66 (24): 11763–70. doi:10.1158/0008-5472.CAN-06-3165. PMID 17178872.
• Lu ZX, Peng J, Su B (2007). "A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory". Hum. Mutat. 28 (10): 978–84. doi:10.1002/humu.20547. PMID 17487847.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.244