KLK8

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.[5][6][7][8][9]

KLK8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein related peptidase 8
External IDsOMIM: 605644 MGI: 1343327 HomoloGene: 21410 GeneCards: KLK8
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.41Start50,996,007 bp[1]
End51,002,711 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

11202

259277

Ensembl

ENSG00000129455

ENSMUSG00000064023

UniProt

O60259

Q61955

RefSeq (mRNA)

NM_001281431
NM_007196
NM_144505
NM_144506
NM_144507

NM_008940
NM_001324398

RefSeq (protein)

NP_001268360
NP_009127
NP_653088
NP_653089
NP_653090

NP_001311327
NP_032966

Location (UCSC)Chr 19: 51 – 51 MbChr 7: 43.8 – 43.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000129455 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000064023 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (May 1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur J Biochem. 260 (3): 627–34. doi:10.1046/j.1432-1327.1999.00213.x. PMID 10102990.
  6. Yoshida S, Taniguchi M, Hirata A, Shiosaka S (Aug 1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene. 213 (1–2): 9–16. doi:10.1016/S0378-1119(98)00232-7. PMID 9714609.
  7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
  8. Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
  9. "Entrez Gene: KLK8 kallikrein-related peptidase 8".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: S01.244


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