EVT-101

EVT-101, also known as ENS-101, is an experimental medication which originated from Roche and is under development by Evotec AG for the treatment of major depressive disorder.[1] It acts as a selective NMDA receptor subunit 2B (NR2B) antagonist.[1][2] As of November 2017, EVT-101 is in phase II clinical trials for major depressive disorder, although no recent reports of development have been identified.[1] The drug was first claimed by Roche in 2002.[3]

EVT-101

Clinical data
Other names	ENS-101
Drug class	NMDA receptor antagonist
Identifiers
IUPAC name 5-[3-(Difluoromethyl)-4-fluorophenyl]-3-[(2-methylimidazol-1-yl)methyl]pyridazine
CAS Number	627525-33-1 1166398-51-1 1189088-41-2 (HCl)
PubChem CID	22240172
ChemSpider	11255877
UNII	14DN1WB87S
ChEMBL	ChEMBL3545350
Chemical and physical data
Formula	C16H13F3N4
Molar mass	318.303 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1=NC=CN1CC2=NN=CC(=C2)C3=CC(=C(C=C3)F)C(F)F
InChI InChI=1S/C16H13F3N4/c1-10-20-4-5-23(10)9-13-6-12(8-21-22-13)11-2-3-15(17)14(7-11)16(18)19/h2-8,16H,9H2,1H3 Key:BOVUHBFXPNLTKF-UHFFFAOYSA-N

See also

• List of investigational antidepressants

References

1. http://adisinsight.springer.com/drugs/800023880
2. https://www.evotec.com/uploads/media_library/14/AC_SfN_Poster_2010_FINAL.pdf
3. Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC (2012). "Novel NMDA receptor modulators: an update". Expert Opin Ther Pat. 22 (11): 1337–52. doi:10.1517/13543776.2012.728587. PMC 3677696. PMID 23009122.

External links

• EVT-101 - AdisInsight