Deoxyhypusine monooxygenase

In enzymology, a deoxyhypusine monooxygenase (EC 1.14.99.29) is an enzyme that catalyzes the chemical reaction

protein N6-(4-aminobutyl)-L-lysine + AH2 + O2 protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O
deoxyhypusine monooxygenase
Identifiers
EC number1.14.99.29
CAS number101920-83-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are a protein-bound N6-(4-aminobutyl)-L-lysine, an electron acceptor AH2, and O2, and its 3 products are protein-bound N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine, the reduction product A, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating). Other names in common use include deoxyhypusine hydroxylase, and deoxyhypusine dioxygenase.

References

    • Abbruzzese A, Park MH, Folk JE (1986). "Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization". J. Biol. Chem. 261 (7): 3085–9. PMID 3949761.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.