D-arabinose 1-dehydrogenase (NAD(P)+)
In enzymology, a D-arabinose 1-dehydrogenase [NAD(P)+] (EC 1.1.1.117) is an enzyme that catalyzes the chemical reaction
- D-arabinose + NAD(P)+ D-arabinono-1,4-lactone + NAD(P)H + H+
D-arabinose 1-dehydrogenase [NAD(P)+] | |||||||||
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Identifiers | |||||||||
EC number | 1.1.1.117 | ||||||||
CAS number | 37250-48-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The 3 substrates of this enzyme are D-arabinose, NAD+, and NADP+, whereas its 4 products are D-arabinono-1,4-lactone, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-arabinose:NAD(P)+ 1-oxidoreductase. This enzyme is also called D-arabinose 1-dehydrogenase [NAD(P)+].
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H6E.
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References
- Cline AL, Hu AS (1965). "The isolation of three sugar dehydrogenases from a psuedomonad [sic]". J. Biol. Chem. 240 (11): 4488–92. PMID 5845847.
- Cline AL, Hu AS (1965). "Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4493–7. PMID 5845848.
- Cline AL, Hu AS (1965). "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4498–502. PMID 5845849.
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