Cells at Work!

Cells at Work! (Japanese: はたらく細胞, Hepburn: Hataraku Saibō) is a Japanese manga series written and illustrated by Akane Shimizu. It features the anthropomorphized cells of a human body, with the two main protagonists being a red blood cell and a white blood cell she frequently encounters. The manga has been serialized in Kodansha's shōnen manga magazine Monthly Shōnen Sirius since January 2015. It is licensed in North America by Kodansha USA.

Cells at Work!
The cover of the first volume of Cells at Work!, featuring Red Blood Cell AE3803 and White Blood Cell U-1146
はたらく細胞
(Hataraku Saibō)
GenreBiology,[1] comedy[2]
Manga
Written byAkane Shimizu
Published byKodansha
English publisher
MagazineMonthly Shōnen Sirius
DemographicShōnen
Original runJanuary 26, 2015 – present
Volumes5
Manga
Cells at Work!: Bacteria!
Illustrated byHaruyuki Yoshida
Published byKodansha
English publisher
Kodansha USA
MagazineNakayoshi
DemographicShōjo
Original runMay 2017 – present
Volumes7
Manga
Cells NOT at Work!
Illustrated byMoe Sugimoto
Published byKodansha
English publisher
Kodansha USA
MagazineMonthly Shōnen Sirius
DemographicShōnen
Original runJuly 26, 2017 – present
Volumes3
Manga
Cells at Work! Code Black
Written byShigemitsu Harada
Illustrated byIssei Hatsuyoshi
Published byKodansha
English publisher
Kodansha USA
MagazineMorning
DemographicSeinen
Original runJune 7, 2018 – present
Volumes6
Anime television series
Directed by
  • Kenichi Suzuki (season 1)
  • Hirofumi Ogura (season 2)
Produced byYuma Takahashi
Written by
  • Yūko Kakihara
  • Kenichi Suzuki
Music by
StudioDavid Production
Licensed by
Original networkTokyo MX, BS11, GYT, GTV, MBS, TV Aichi, RKB, HBC
English network
Animax Asia
Original run July 8, 2018 – present
Episodes13 + Special
Light novel
Written byYui Tokiumi
Illustrated byAkane Shimizu
Published byKodansha
DemographicShōnen
PublishedJuly 12, 2018
Volumes1
Manga
Cells at Work and Friends!
Written byKanna Kurono
Illustrated byMio Izumi
Published byKodansha
English publisher
Kodansha USA
MagazineBessatsu Friend
DemographicShōjo
Original runJanuary 12, 2019 – present
Volumes4
Manga
Cells at Work!: Platelets!
Written byYuuko Kakihara
Illustrated byYasu
Published byKodansha
English publisher
Kodansha USA
MagazineMonthly Shōnen Sirius
DemographicShōnen
Original runMay 25, 2019 – present
Volumes2
Manga
Cells at Work!: Baby!
Illustrated byYasuhiro Fukuda
Published byKodansha
English publisher
Kodansha USA
MagazineMorning
DemographicSeinen
Original runOctober 17, 2019 – present
Volumes2
Manga
Cells at Work!: Lady!
Written byShigemitsu Harada
Illustrated byAkari Otokawa
Published byKodansha
MagazineMorning two
DemographicSeinen
Original runJanuary 22, 2020 – present
Volumes1
Anime film
"Hataraku Saibō!!" Saikyō no Teki, Futatabi. Karada no Naka wa "Chō" Ōsawagi!
Directed byHirofumi Ogura
Written byYūko Kakihara
Music by
  • Kenichiro Suehiro
  • MAYUKO
StudioDavid Production
ReleasedSeptember 5, 2020 (2020-09-05)
Anime television series
Cells at Work! Code Black
Directed byHideyo Yamamoto
Written byHayashi Mori
Music byYugo Kanno
StudioLiden Films
Original run January 2021 – scheduled

An anime television series adaptation by David Production ran from July to September 2018. A theatrical anime titled "Hataraku Saibō!!" Saikyō no Teki, Futatabi. Karada no Naka wa "Chō" Ōsawagi! will premiere in September 2020. A second season is scheduled to premiere in January 2021.

Plot

The story takes place inside the human body, where trillions of anthropomorphic cells each do their job to keep the body healthy. The series largely focuses on two such cells; a rookie red blood cell, AE3803, who often gets lost during deliveries, and a relentless white blood cell, U-1146, who fights against any germs that invade the body.

Characters
Erythrocyte / Red Blood Cell (AE3803) (赤血球, Sekkekkyū)
Voiced by: Kana Hanazawa[3] (Japanese); Cherami Leigh[4] (English)
A red blood cell who has just started her job, delivering oxygen, carbon dioxide and different nutrients all over the body. She meets Neutrophil when he saves her from an attacking pneumococcus bacterium. She is clumsy and gets lost often, but is determined to perform to the best of her ability. It is later revealed that she had encountered Neutrophil when they were younger, after he saved her from a bacterium.
Neutrophil (好中球, Kōchūkyū) / White Blood Cell (U-1146) (白血球, Hakkekkyū)
Voiced by: Tomoaki Maeno[3] (Japanese); Billy Kametz[4] (English)
A type of white blood cell, whose job is to kill pathogens infecting the body. Despite his violent and ruthless occupation, he's quite soft-spoken and gentle. When he was still in school as a young cell, he saved AE3803 from a bacterium after she got lost in a training exercise.
Killer T Cell (キラーT細胞, Kirā Tī Saibō)
Voiced by: Daisuke Ono[3] (Japanese); Robbie Daymond[4] (English)
A type of white blood cell that recognizes and kills various foreign matter and unhealthy cells. He is aggressive, cocky and rowdy, brutally taking pleasure in slaughtering pathogens and unhealthy cells. He especially looks down on white blood cells forming relationships with non-white blood cells, like Neutrophil's close friendship with Red Blood Cell. He is the sergeant of the Killer T Cells and is a harsh teacher to his students, the Naive T Cells. He has negative relationships with Helper T Cell and NK Cell, the former being his superior in the Killer T Division. In his youth, he was considered to be weak like the rest of the young T Cells, being only able to survive and complete training through the help of Helper T Cell, which at least made him stronger.
Macrophage (マクロファージ, Makurofāji) / Monocyte (単球, Tankyū)
Voiced by: Kikuko Inoue[3] (Japanese); Laura Post[4] (English)
A type of white blood cell. She and her kind appear as lovely maids in big dresses, armed with a variety of large weapons to fight various invasive pathogens, and are often shown smiling cheerfully even in the middle of combat. While inside blood vessels, she and her kind take on the role of monocytes, and wear hazmat suits over their dresses.
Platelet (血小板, Kesshōban)
Voiced by: Maria Naganawa[3] (Japanese); Xanthe Huynh[4] (English)
A type of cell responsible for reconstructing the body after various injuries. They are depicted as children, due to their small cell size, and act as construction and repair crew within the body. One platelet serves as their leader and she is most prominently featured in the show.
Helper T Cell (ヘルパーT細胞, Herupā Tī Saibō)
Voiced by: Takahiro Sakurai[5] (Japanese); Ray Chase[4] (English)
A type of T Cell that determines strategy and courses of action for dealing with foreign invaders. He is the main commander of the Killer T Division and has an intellectual and smooth disposition, putting him at big odds with the rough and tough Killer T Cell, despite having underwent T Cell training together with him.
Regulatory T Cell (制御性T細胞, Seigyosei Tī Saibō)
Voiced by: Saori Hayami[5] (Japanese); Erica Mendez[4] (English)
A type of T Cell that mediates and regulates the correct function and magnitude of immunological responses. She usually acts as Helper T Cell's secretary, though she is capable of fighting when necessary. She went through T Cell training alongside Killer T Cell and Helper T Cell.
Naive T Cell (ナイーブT細胞, Naību T Saibō)
Voiced by: Mutsumi Tamura (Japanese); Laura Stahl[6] (English)
A rookie T Cell who is too frightened to fight invasive microorganisms, until Dendritic Cell helps him transform into Effector T Cell. He and his kind are the students of Killer T Cell, from whom they receive harsh treatment and austere training.
Effector T Cell (エフェクターT細胞, Efekutā T Saibō)
Voiced by: Kenji Nomura (Japanese); Chris Tergliaferra[6] (English)
A Naive T Cell transformed into a large, muscular and powerful T Cell.
Eosinophil (好酸球, Kōsankyū)
Voiced by: M.A.O[5] (Japanese); Kayli Mills[4] (English)
A type of white blood cell who is acquainted with White Blood Cell since they grew up in the same bone marrow. She feels inferior to the other immune cells because of her inability to fight off bacteria and viruses, but she shows her true worth by killing a parasitic Anisakis when the other cells could not. She handles a bident as her weapon of choice.
Dendritic Cell (樹状細胞, Jujō Saibō)
Voiced by: Nobuhiko Okamoto[5] (Japanese); Griffin Burns[4] (English)
Depicted as a messenger dressed in green stationed inside a call center resembling a tree. He can stimulate Naive T Cells and transform them into Effector T Cells. He owns a camera which he always uses to take pictures of events he deems important and stores them in picture albums, some of which are sources of shame and humiliation for the other cells.
Memory Cell (記憶細胞, Kioku Saibō)
Voiced by: Yuichi Nakamura[7] (Japanese); Dave Vincent[6] (English)
A paranoid and neurotic cell whose job is to remember past infections and allergies so that the immunity system can be ready for them. However, he is scatterbrained and it is difficult for him to sort out his memories, often panicking and screaming whenever disaster strikes.
Mast Cell (マスト細胞, Masuto Saibō)
Voiced by: Ayako Kawasumi[7] (Japanese); Maureen Price[6] (English)
A cell whose job is to monitor and release histamines in response to allergic and inflammatory reactions. She always follows the instructions in her book no matter the situations and is unpopular due to her lack of consideration of what her actions do to the other cells. Also known as "Fat Cell", she gets irked whenever she is referred to with that name.
Senior Red Blood Cell (AA5100) (先輩赤血球, Senpai Sekkekkyū)
Voiced by: Aya Endo[7] (Japanese); Kira Buckland[6] (English)
An older red blood cell who sometimes guides and teaches AE3803 on how to properly perform her occupation.
Junior Red Blood Cell (NT4201) (後輩赤血球, Kohai Sekkekkyū)
Voiced by: Yui Ishikawa (Japanese); Jeannie Tirado (English)
A young but overly serious red blood cell who becomes AE3803's student.
B Cell (B細胞, Bī Saibō)
Voiced by: Shōya Chiba[8] (Japanese); Erik Scott Kimerer[4] (English)
A white blood cell who carries a weapon that shoots antibodies. He is often annoyed and jealous about not receiving as much credit as the Killer T Cells do. He also has an antagonistic relationship with Mast Cell, as their combined functions only cause grave disasters for the other cells.
Basophil (好塩基球, Kōenkikyū)
Voiced by: Tomokazu Sugita (Japanese); D. C. Douglas[6] (English)
A mysterious and poetic character whose real occupation is unknown, appearing during a food-borne infection to make cryptic commentaries on the disastrous events unfolding.
NK Cell (NK細胞, NK Saibō)
Voiced by: Toa Yukinari (Japanese); Morgan Berry[4] (English)
She patrols the whole body for viruses, bacteria and abnormal cells, with her weapon of choice being a machete. She has a smug demeanor, is somewhat condescending towards other cells and her relationship with Killer T Cell is akin to that of an intense sibling rivalry.
Cancer Cell (がん細胞, Gan Saibō)
Voiced by: Akira Ishida[9] (Japanese); Khoi Dao[6] (English)
An antagonistic cell bent on creating a world where cells no longer have to kill each other, even if it means risking the life of the body.[10] He appears in only two episodes in the anime, but is a recurring character in the manga.
Narrator (ナレーション, Narēshon)
Voiced by: Mamiko Noto[8] (Japanese); Karen Strassman[6] (English)

Media

Manga

The manga was launched in Kodansha's shōnen manga magazine Monthly Shōnen Sirius on January 26, 2015.[11] Kodansha has collected the manga into five tankōbon volumes as of August 2017.[12]

Kodansha USA announced that it had licensed Cells at Work! in North America on March 21, 2016.[13] The manga is also licensed in Taiwan by Tong Li Publishing.[14] Kodansha USA also announced that it has licensed Cells at Work! Code Black.[15] Kodansha USA has also licensed three other spin-offs Cells at Work!: Bacteria!, Cells at Work!: Platelets! and Cells at Work!: Baby!.[16]

Spin-offs

The manga received a spin-off in the May 2017 issue of Nakayoshi called Cells at Work!: Bacteria! (はたらく細菌; "Bacteria at Work") by Haruyuki Yoshida,[17] which follows the lives of good and bad bacteria in the intestines.[18][19] On June 3, 2020, it was announced that Cells at Work!: Bacteria! would end in July 3, 2020.[20]

Another spin-off, titled Cells NOT at Work! (はたらかない細胞; "Cells That Don't Work") by Moe Sugimoto, about immature red blood cells (erythroblasts) that do not want to work, was launched in the September 2017 issue of Monthly Shōnen Sirius.[21]

The manga received another spin-off titled Cells at Work! Code Black (はたらく細胞BLACK), set in a "black" environment of a human body suffering an unhealthy lifestyle, that runs in Weekly Morning since June 7, 2018. It is written by Shigemitsu Harada, with illustrations by Issei Hatsuyoshi and supervision by Shimizu.[22]

The manga received another spin-off titled Cells at Work and Friends! (はたらく細胞フレンド; "Cells at Work! Friend"), which centers around a Killer T Cell who is normally strict with himself and others, but wants to have fun during his free time. He also wants to make friends but does not want to ruin his reputation. The series began running in Bessatsu Friend on January 12, 2019. It is written by Kanna Kurono, and illustrated by Mio Izumi.[23]

Another spin-off series focusing on the platelet characters, titled Cells at Work!: Platelets! (はたらく血小板ちゃん, Platelets at Work) written by Kanna Kurono and illustrated by Mio Izumi, began serialization in the June issue of Monthly Shōnen Sirius that was released on May 25, 2019.[24]

Another spin-off series focusing cells inside the body of a baby 40 weeks since conception and nearing delivery, with the cells knowing nothing, titled Cells at Work!: Baby! (はたらく細胞ＢＡＢＹ) illustrated by Yasuhiro Fukuda, was launched in the 45th issue of Weekly Morning on October 17, 2019.[25]

Another spin-off series focusing on cells in the body of an adult woman, titled Cells at Work!: Lady! (はたらく細胞ＬＡＤＹ) written by Harada and illustrated by Akari Otokawa, was launched in the March issue of Monthly Morning Two on January 22, 2020.[26]

Volume list
Cells at Work!
No.Japan release dateJapan ISBNNorth America release dateNorth America ISBN
1 July 9, 2015[27]978-4-06-376560-1November 1, 2016[28]978-1-63236-356-5
  • 01. "Pneumococcus" (肺炎球菌, Haienkyūkin)
  • 02. "Cedar Pollen Allergy" (スギ花粉アレルギー, Sugikafun Arerugī)
  • 03. "Influenza" (インフルエンザ, Infuruenza)
  • 04. "Scrape Wound" (すり傷, Surikizu)
2 November 20, 2015[29]978-4-06-376589-2December 27, 2016[30]978-1-63236-357-2
  • 05. "Food Poisoning" (食中毒, Shokuchūdoku)
  • 06. "Heat Stress" (熱中症, Netchūshō)
  • 07. "Erythroblasts and Myelocytes" (赤芽球と骨髄球, Sekigakyū to Kotsuzuikyū)
  • 08. "Cancer Cells (Part I)" (がん細胞（前編）, Gansaibō (Zenpen))
  • 09. "Cancer Cells (Part II)" (がん細胞（後編）, Gansaibō (Kōhen))
3 June 9, 2016[31]978-4-06-390633-2March 28, 2017[32]978-1-63236-390-9
  • 10. "The Circulatory System" (血液循環, Ketsueki Junkan)
  • 11. "The Common Cold" (風邪症候群, Kaze Shōkōgun)
  • 12. "Thymocytes" (胸腺細胞, Kyōsen Saibō)
  • 13. "Acquired Immunity" (獲得免疫, Kakutoku Men'eki)
  • 14. "Acne" (ニキビ, Nikibi)
4 November 30, 2016[33]978-4-06-390664-6May 2, 2017[34]978-1-63236-391-6
  • 15. "Staphylococcus aureus" (黄色ブドウ球菌, Ōshoku Budō Kyūkin)
  • 16. "Dengue Fever" (デング熱, Dengu Netsu)
  • 17. "Hypovolemic Shock (Part I)" (出血性ショック（前編）, Shukketsusei Shokku (Zenpen))
  • 18. "Hypovolemic Shock (Part II)" (出血性ショック（後編）, Shukketsusei Shokku (Kōhen))
  • 19. "Peyer's Patch" (パイエル板, Paieuru Ban)
5 August 9, 2017[12]978-4-06-390720-9November 21, 2017[35]978-1-63236-426-5
  • 20. "H. Pylori" (ピロリ菌, Pirorikin)
  • 21. "Antigenic Shift" (抗原変異, Kōgen Hen'i)
  • 22. "Cytokines" (サイトカイン, Saitokain)
  • 23. "Harmful Bacteria" (悪玉菌, Akudamakin)
  • 24. "Cancer Cell II (Part I)" (がん細胞２（前編）, Gansaibō Tsū (Zenpen))
  • 25. "Cancer Cell II (Part II)" (がん細胞２（後編）, Gansaibō Tsū (Kōhen))
Cells at Work!: Bacteria!
No.Japan release dateJapan ISBN
1 February 9, 2018[36]978-4-06-510910-6
2 July 9, 2018[37]978-4-06-512138-2
3 October 9, 2018[38]978-4-06-513423-8
4 February 8, 2019[39]978-4-06-514602-6
5 July 9, 2019[40]978-4-06-516434-1
6 December 9, 2019[41]978-4-06-518183-6
7 August 6, 2020[42]978-4-06-520572-3
Cells NOT at Work!
No.Japan release dateJapan ISBN
1 July 9, 2018[43]978-4-06-511982-2
2 February 8, 2019[44]978-4-06-514461-9
3 December 9, 2019[45]978-4-06-517763-1
Cells at Work! Code Black
No.Japan release dateJapan ISBNEnglish release dateEnglish ISBN
1 July 9, 2018[46]978-4-06-512067-5September 3, 2019[47]978-1-63236-894-2
  • 01. "Smoking, Germs, the Beginning of an End" (喫煙、細菌、終わりの始まり, Kitsuen, Saikin, Owarinohajimari)
  • 02. "Liver, Alcohol, Arrogance" (肝臓、アルコール、誇り, Kanzō, Arukōru, Hokori)
  • 03. "Erection, Ejaculation, Emptiness" (勃起、射精、虚無, Bokki, Shasei, Kyomu)
  • 04. "Gonococcus, Invasion" (淋菌、襲来, Rinkin, Shūrai)
  • 05. "Overwork, Confusion, Hair Loss" (過重労働、錯乱、脱毛, Ka jūrōdō, Sakuran, Datsumō)
2 September 21, 2018[48]978-4-06-512760-5November 5, 2019[49]978-1-63236-895-9
  • 06. "Abnormalities, Athlete's Foot, A Reason for Working" (異変、水虫、働く意味, Ihen, Mizumushi, Hataraku Imi)
  • 07. "Stomach Ulcer, Friendship, Loss" (胃潰瘍、友情、喪失, Ikaiyō, Yūjō, Sōshitsu)
  • 08. "Despair, Gout, Mutiny" (自暴自棄、痛風、反乱, Jibōjiki, Tsūfū, Hanran)
  • 09. "Return, Heart, Demise" (復帰、心臓、終焉, Fukki, Shinzō, Shūen)
  • 10. "Heart Attack, Resuscitation, Change" (心筋梗塞、蘇生、変化, Shinkinkōsoku, Sosei, Henka)
3 February 22, 2019[50]978-4-06-514640-8January 21, 2020[51]978-1-63236-896-6
  • 11. "Peace, Polyp, Catastrophe" (平和、ポリープ、天変地異, Heiwa, Porīpu, Tenpenchii)
  • 12. "Energy Drink, Nosebleed, Quota" (エナジードリンク、鼻血、ノルマ, Enajīdorinku, Hanadji, Noruma)
  • 13. "Kidney, Urolithiasis, Hematuria" (腎臓、尿路結石、血尿, Jinzō, Nyōrokessekishō, Ketsunyō)
  • 14. "Urinary Tract Infection, Silence, Tears" (尿路感染、沈黙、涙, Nyōrokansen, Chinmoku, Namida)
  • 15. "Sebum, Aged Odor, Last Job" (皮脂、加齢臭、最後の仕事, Hishi, Kareishū, Saigo no Shigoto)
  • 16. "Calf, Power Hara, Nightmare Again" (ふくらはぎ、パワハラ、悪夢再び, Fuku-ra Hagi, Pawahara, Akumufutatabi)
  • 17. "Pulmonary Thrombosis, Tact, Reunion" (肺血栓、機転、再会, Haikessen, Kiten, Saikai)
4 June 21, 2019[52]978-4-06-516113-5March 24, 2020[53]978-1-63236-943-7
  • 18. "Pancreas, Insulin, Destroyed" (膵臓、インスリン、決壊, Suizō, Insurin, Kekkai)
  • 19. "Exhaustion, Saccharification, Excuse" (疲弊、糖化、言い訳, Hihei, Tōka, Iiwake)
  • 20. "AGA, Semen, Losing Work" (ＡＧＡ、精液、無くなる仕事, Ēga, Seieki, Nakunaru Shigoto)
  • 21. "Return, Responsibility, Hemorrhoids" (復帰、責任、痔, Fukki, Sekinin, Ji)
  • 22. "Fistula, Responsibility, Achievement" (痔瘻、責任、手柄, Jirō, Sekinin, Tegara)
  • 23. "Zoster, Mission, Companion" (帯状疱疹、使命、仲間, Taijōhōshin, Shimei, Nakama)
  • 24. "Sugar Content, Blood Vessels, Catastrophe" (糖分、血管、破局, Tōbun, Kekkan, Hakyoku)
5 October 23, 2019[54]978-4-06-517225-4August 11, 2020[55]978-1-64651-034-4
6 April 23, 2020[56]978-4-06-519207-8October 13, 2020[57]978-1-64651-149-5
Cells at Work and Friends!
No.Japan release dateJapan ISBN
1 June 7, 2019[58]978-4-06-515522-6
2 November 7, 2019[59]978-4-06-517636-8
3 March 9, 2020[60]978-4-06-518909-2
4 July 13, 2020[61]978-4-06-520155-8
Cells at Work!: Platelets!
No.Japan release dateJapan ISBN
1 January 9, 2020[62]978-4-06-518185-0
2 June 9, 2020[63]978-4-06-519798-1
Cells at Work!: Baby!
No.Japan release dateJapan ISBN
1 January 9, 2020[64]978-4-06-518231-4
2 July 20, 2020[65]978-4-06-519640-3
Cells at Work!: Lady!
No.Japan release dateJapan ISBN
1 July 20, 2020[66]978-4-06-519908-4

Anime

An anime television series adaptation was announced in January 2018. It is directed by Kenichi Suzuki and animated by David Production, with scripts written by Suzuki and Yūko Kakihara, and character designs by Takahiko Yoshida. The series' music is composed by Kenichiro Suehiro and MAYUKO. The anime series premiered on July 8, 2018 on Tokyo MX and other channels.[7][67][68] The series ran for 13 episodes.[69] Aniplex of America licensed the series in North America and simulcast it on Crunchyroll.[70] Madman Entertainment simulcasted Australia and New Zealand on AnimeLab,[71] while Animax Asia simulcast the series for the Southeast Asia region.[72] MVM Entertainment acquired the series for distribution in the United Kingdom and Ireland.[73] The opening theme is "Mission! Health Comes First" (ミッション！ 健・康・第・イチ, Mission! Ken - Kō - Dai - Ichi) by Kana Hanazawa, Tomoaki Maeno, Daisuke Ono, and Kikuko Inoue in Japanese and Cherami Leigh, Billy Kametz, Robbie Daymond and Laura Post in English,[7][74] while the ending theme is "CheerS" by ClariS.[75] A special episode premiered on December 27, 2018.[76] Aniplex of America released the English dub on August 27, 2019.[4]

On March 23, 2019, the official Twitter account announced that the series will receive a second season.[77] The season will premiere in January 2021.[78] The main staff at David Production is returning for producing the second season, with the exception of director Kenichi Suzuki being replaced by director Hirofumi Ogura.[79]

In April 2020, the 20th issue of Morning magazine revealed that an adaptation of Cells at Work! Code Black would air in January 2021.[80] The series is being directed by Hideyo Yamamoto with series composition by Hayashi Mori. Yugo Kanno is composing the music, Eiji Akibo is designing the characters for animation, and Liden Films is producing the series.[81]

No. Title[82] Original air date
1"Pneumococcus"
Transcription: "Haienkyūkin" (Japanese: 肺炎球菌)		July 7, 2018 (2018-07-07)
Inside a human body, a red blood cell, named AE3803, is rescued from a sudden attack from a group of Pneumococcus bacteria by a white blood cell, named U-1146. Later, as AE3803 tries to find her way to the lungs to make the delivery, she discovers one of the bacteria has escaped and is planning an attack on the lungs, so she and U-1146 accompany each other to the lungs to pursue it. Upon reaching the lungs and parting ways with U-1146, AE3803 discovers Pneumococcus had been hiding in her package the entire time, waiting to target red blood cells for their nutrients. However, U-1146, who had caught onto the bacterium's plan, arrives in time and lures the bacterium into a trap, where he is ultimately sneezed out of the lungs.
2"Scrape Wound"
Transcription: "Surikizu" (Japanese: すり傷)		July 14, 2018 (2018-07-14)
The red blood cells find themselves in trouble when the vessel they are travelling on is broken by a skin abrasion, with U-1146 and the other white blood cells forced to deal with all the germs that come through as a result. As the bacteria plot to eliminate all the neutrophils before backup can arrive, the white blood cells manage to hold them off while the platelets arrive to clot the wound, preventing more germs from getting inside.
3"Influenza"
Transcription: "Infuruenza" (Japanese: インフルエンザ)		July 21, 2018 (2018-07-21)
Naive T Cell is patrolling the body for influenza virus proliferation. But since he's never taken on the enemy before, he's completely terrified and useless. He finally ends up fleeing the battlefield, where the veteran Killer T Cells, Neutrophils and Macrophages are battling. Naive T Cell is filled with self-loathing until Dendritic Cell sees him and speaks to him kindly. This encouragement transforms him into Effector T Cell, a much braver and stronger form that joins the other immune cells in wiping out the influenza virus. However, a surviving virus mutates into Type A and proliferates again, so the fighting goes on.
4"Food Poisoning"
Transcription: "Shokuchūdoku" (Japanese: 食中毒)		July 28, 2018 (2018-07-28)
A band of Vibrio bacteria invades the stomach. Basophil warns the immune cells about it, but confuses everyone by speaking cryptically. The immune cells defeat the invaders, but one of them, Eosinophil, was unable to land any good hits and had to be rescued. The other cells mock her as a weakling, except AE3803 and U-1146. The stomach then gets invaded by a massive Anisakis parasite. The immune cells are no match for it, but Eosinophil explains she is designed to battle parasites and kills it with a single stab. The other cells apologize for making fun of her and praise her as a heroine.
5"Cedar Pollen Allergy"
Transcription: "Sugikafun Arerugī" (Japanese: スギ花粉アレルギー)		August 4, 2018 (2018-08-04)
The body inhales cedar pollen, which unleashes gigantic allergens. Though U-1146 points out the creatures are mindless and non-malicious, Memory Cell claims they bring impending doom. B Cell easily defeats the allergens, but Mast Cell releases a profuse amount of histamines within the body, which causes violent allergic reactions that damage the surroundings. Just as everyone blames Mast Cell for the destruction, the body takes a steroid to treat the allergy. The steroid appears in the form of a robot that indiscriminately destroys its surroundings until it loses power. The survivors realize all of this was caused by following Memory Cell's claims and trying to attack the allergens.
6"Erythroblasts and Myelocytes"
Transcription: "Sekigakyū to Kotsuzuikyū" (Japanese: 赤芽球と骨髄球)		August 11, 2018 (2018-08-11)

AE3803 gets lost again and finds herself in her birthplace, the Red Bone Marrow. She reminisces on being a young Erythroblast being trained by a Macrophage on how to be a Red Blood Cell. One day, while practicing to evacuate from bacteria, she got lost and was separated from the others. She got captured by a Pseudomonas bacterium who intended to torture and kill her before moving on to other blood cells. A young Myelocyte came to her rescue, and although no match for the bacterium, bought enough time for Macrophage and a Neutrophil to arrive and kill the bacterium. She thanked the Myelocyte for helping her and they went their separate ways hoping to someday see each other again. In the present, she runs into U-1146. As he offers to guide her to her destination, she suspects the Myelocyte who saved her grew up to be U-1146.

Later, U-1146 saves a Normal Cell from a Cancer Cell. The Normal Cell explains there are more Cancer Cells in his apartment complex. The Normal Cell leads U-1146, Killer T Cell, and NK Cell to his apartment, but Killer T Cell continually trades spats with NK Cell and stubbornly refuse working with her. The group splits up and once they are alone, NK Cell reveals she knew the Normal Cell was actually a Cancer Cell in disguise.
7"Cancer Cells"
Transcription: "Gansaibō" (Japanese: がん細胞)		August 18, 2018 (2018-08-18)
NK Cell battles the Cancer Cell, who is able to shapeshift and spread into the surrounding environment. Meanwhile, U-1146 and Killer T Cell run into Cancer Cell's multiplying clones. The Cancer Cells order massive quantities of nutrients to be delivered to the apartment to greedily sustain themselves, but AE3803 feels suspicious and alerts the rest of the immune system. U-1146, Killer T Cell and NK Cell are cornered and about to be killed, until the other immune cells arrive. All the Cancer Cells are wiped out, with NK Cell delivering the final blow against the original one, but he vows revenge before dying in front of U-1146.
8"Blood Circulation"
Transcription: "Ketsueki Junkan" (Japanese: 血液循環)		August 25, 2018 (2018-08-25)
AE3803 becomes tired of always getting lost and resolves to circulate the body without guidance. After a difficult journey, she manages to travel through the heart, then the lungs to exchange carbon dioxide with oxygen, then to the body's cells to exchange oxygen with carbon dioxide. U-1146 clandestinely followed her and helped return her dropped notes and hat, then killed some germs who tried to ambush her, all without her noticing his presence. U-1146 later tells Killer T Cell that he has gained an appreciation for all the hard work the Red Blood Cells do every day and hopes the immune cells can live in harmony with other cells, but Killer T Cell angrily punches him and orders him to get back to work. AE3803 meets U-1146 and tells him how her day went. Killer T Cell walks around seeing several immune cells mingling with other cells and irritably denies being envious.
9"Thymocytes"
Transcription: "Kyōsen Saibō" (Japanese: 胸腺細胞)		September 1, 2018 (2018-09-01)
As Killer T Cell and Helper T Cell get into an argument about the former's harsh training methods, Dendritic Cell shares his photo album with the Naive T Cells and explains the two's shared past. While training in the Thymus, the future Helper T Cell and Regulatory T Cell easily passed all the hand to hand combat and obstacle courses, but the future Killer T Cell struggled. The future Helper T Cell was disdainful of him for this, but eventually gave him advice that helped him pass the final test. Killer T Cell vowed to become a worthy defender of the body, while Helper T Cell decided to become a commander. In the present, Killer T Cell and Helper T Cell notice the photo album. Severely embarrassed, they both try unsuccessfully to take it from Dendritic Cell in order to burn it. Regulatory T Cell muses that they are both still morons as they were in training.
10"Staphylococcus aureus"
Transcription: "Ōshoku Budō Kyūkin" (Japanese: 黄色ブドウ球菌)		September 8, 2018 (2018-09-08)
AE3803 is rescued from a germ by a mysterious immune cell called Monocyte, who doesn't speak and wears a hazmat suit. Later, the nasal cavity gets invaded by a band of Staphylococcus aureus. Vowing revenge for one of their number who was killed in "Scrape Wound", they combine their bodies into a powerful giant who is able to trap the white blood cells in a net of fibrin. A squad of Monocytes appears and sheds their hazmat suits to reveal that they are Macrophages; Monocytes being one of the many roles they play. The Macrophages easily defeat the invaders. As the white blood cells thank the Macrophages for saving everyone, AE3803 asks one of them how they fit their enormous dresses inside the hazmat suits, but she tells her it is a secret.
11"Heat Stress"
Transcription: "Netchūshō" (Japanese: 熱中症)		September 15, 2018 (2018-09-15)
The body suffers from heat stroke, leading to a heat wave inside and the supply of fluids being depleted. To make matters worse, a Bacillus cereus bacterium, who is not bothered by the heat, invades the body. While the other cells struggle to cope with the extreme heat, U-1146 pursues the bacterium, but grows fatigued. Just when it seems that all is lost, the body gets an injection of fluids, reviving everyone and allowing U-1146 to kill the bacterium.
12"Hemorrhagic Shock (Part 1)"
Transcription: "Shukketsusei Shokku (Zenpen)" (Japanese: 出血性ショック(前編))		September 22, 2018 (2018-09-22)
AE3803 is assigned to be a mentor to a new red blood cell named NT4201, but finds herself out of her depth. AE3803 is embarrassed when she gets them lost several times and finds that NT4201 seems to already know about the body, and that she prefers to do her job as efficiently as possible and not associate with non red blood cells. The body suffers a head injury which results in massive blood loss. NT4201 starts to panic due to the change in her perfect schedule, but AE3803 manages to get her back on track. As the body temperature begins to drop, U-1146 defeats germs that entered through the injury, then is horrified to realize the number of red blood cells have depleted.
13"Hemorrhagic Shock (Part 2)"
Transcription: "Shukketsusei Shokku (Kōhen)" (Japanese: 出血性ショック(後編))		September 29, 2018 (2018-09-29)
The platelets struggle to seal the head wound, but increased blood pressure causes even more blood cells to be lost. With so few red blood cells, there are not enough to deliver oxygen to all the cells, and they start to die. The body temperature drops drastically, leading to a blizzard inside. NT4201 falls into despair, and rants that their actions are pointless and the body will die, but AE3803 refuses to give up. The body receives a blood transfusion. The new red blood cells, though confused by their new surroundings, agree to help deliver oxygen, saving the body. As the body's structures are rebuilt, NT4201 apologizes for looking down on AE3803. AE3803 and everybody else gets back to their normal routine.
Special"The Common Cold[83]"
Transcription: "Kaze Shōkōgun" (Japanese: 風邪症候群)		December 26, 2018 (2018-12-26)
A Normal Cell who is bored of his monotonous duties and annoyed by his rowdy Killer T Cell neighbors is befriended by a mysterious cell who doesn't speak and wears a strange hat. The two have fun pulling pranks on various cells. Eventually, the stranger reveals himself to be a cell infected by a virus, with his hat being the replicating virus. He attempts to infect the Normal Cell, but the immune cells arrive in time to wipe out the virus. After identifying the virus as Rhinovirus (The Common Cold), the immune cells lecture the Normal Cell to study so that he can identify pathogens in the future. Now appreciative of his neighbors, the Normal Cell invites the immune cells to a game of badminton.
11.5 (ONA)"Heat Stress: If There Was Pocari Sweat"
Transcription: "Netchūshō: Moshimo Pokari Suetto ga Attara" (Japanese: 熱中症～もしもポカリスエットがあったら～)		July 7, 2019 (2019-07-07)[84]
A commercial version of episode 11 in which the threat of heat stroke is averted thanks to the arrival of Pocari Sweat sports drink.

Film

A theatrical anime titled "Hataraku Saibō!!" Saikyō no Teki, Futatabi. Karada no Naka wa "Chō" Ōsawagi! was announced on July 4, 2020. The main staff at David Production is returning for producing the film, with the exception of director Kenichi Suzuki being replaced by director Hirofumi Ogura. It will premiere on September 5, 2020.[85]

Light novel

A light novel adaptation of the manga titled as Shōsetsu Hataraku Saibō (小説　はたらく細胞) was published on July 12, 2018 by Kodansha. It is written by Yui Tokiumi and illustrated by Akane Shimizu.[86]

Stage play

A stage play adaptation titled Tainai Katsugeki Hataraku Saibō (体内活劇「はたらく細胞」) was announced in the August issue of Kodansha's Monthly Shōnen Sirius magazine.[87] The play was held at Tokyo's Theatre 1010 from November 16 to 25, 2018. The play which was directed by Tsuyoshi Kida, starred Masanari Wada as U-1146 and Kanon Nanaki as AE3803, while Keita Kawajiri wrote the script for the play.[88][89][90] The last performance, which was held on the 25th, was also distributed live.[91]

Mobile app

A game app for iOS and Android mobile devices titled Always Cells at Work (いつでも はたらく細胞, Itsudemo Hataraku Saibō) has been announced and is accepting pre-registration for players.[76]

Reception

Rebecca Silverman of Anime News Network highlighted the educational aspect of the manga despite flaws in presentation of information, and ultimately found the manga entertaining with likable characters.[92] Sean Gaffney of Manga Bookshelf called it a "very fun shonen action manga", complementing the manga's ridiculousness and humor.[93] Ian Wolf of Anime UK News gave the British Blu-ray release of the anime a score of 9 out of 10, and described the show as the most bloody on television, because so many of the characters are blood cells and thus means it contains more blood than shows depicting lots of violence.[94]

The 2016 Kono Manga ga Sugoi! guidebook listed the manga as the seventh top manga for male readers.[95][96] Paul Gravett included the manga in his list of "Top 22 Comics, Graphic Novels & Manga" for October 2016.[97] As of July 2017, the manga had over 1.3 million copies in print.[98] The manga had over 1.5 million copies in print, as of January 2018.[99]

Dr. Satoru Otsuka, postdoctoral fellow in the molecular neuro-oncology department of Emory University School of Medicine in Atlanta, Georgia, praised the series' depiction of cancer cells during the series' seventh episode.[100] Biology teachers at a high school affiliated with China's Southwest University were so impressed with the accuracy of the series that they assigned it as homework for their students.[101]

See also

References
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