Cathepsin O

Cathepsin O is an enzyme that in humans is encoded by the CTSO gene.[5][6]

"CTSO" redirects here. For other uses, see Career and technical student organization.

CTSO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ATK, 1AU0, 1AU2, 1AU3, 1AU4, 1AYU, 1AYV, 1AYW, 1BGO, 1BY8, 1MEM, 1NL6, 1NLJ, 1Q6K, 1SNK, 1TU6, 1U9V, 1U9W, 1U9X, 1VSN, 1YK7, 1YK8, 1YT7, 2ATO, 2AUX, 2AUZ, 2BDL, 2R6N, 3C9E, 3H7D, 3KW9, 3KWB, 3KWZ, 3KX1, 3O0U, 3O1G, 3OVZ, 4DMX, 4DMY, 7PCK, 4LEG, 4N79, 4N8W
Identifiers
Aliases	CTSO, CTSO1, cathepsin O
External IDs	OMIM: 600550 MGI: 2139628 HomoloGene: 1020 GeneCards: CTSO
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q32.1 Start 155,924,118 bp[1] End 155,953,866 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 81,932,601 bp[2] End 81,956,725 bp[2]
Gene ontology Molecular function • peptidase activity • cysteine-type endopeptidase activity • cysteine-type peptidase activity • hydrolase activity Cellular component • lysosome • extracellular Biological process • proteolysis involved in cellular protein catabolic process • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1519	229445
Ensembl	ENSG00000263238 ENSG00000256043	ENSMUSG00000028015
UniProt	P43234	Q8BM88
RefSeq (mRNA)	NM_001334	NM_177662
RefSeq (protein)	NP_001325	NP_808330
Location (UCSC)	Chr 4: 155.92 – 155.95 Mb	Chr 3: 81.93 – 81.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Cathepsin O is a cysteine protease and a member of the cathepsin family and papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cysteine proteinase.[6]

References

1. ENSG00000256043 GRCh38: Ensembl release 89: ENSG00000263238, ENSG00000256043 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028015 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772.
6. "Entrez Gene: cathepsin O".

Further reading

• Shi GP, Chapman HA, Bhairi SM, et al. (1995). "Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2" (PDF). FEBS Lett. 357 (2): 129–34. doi:10.1016/0014-5793(94)01349-6. PMID 7805878.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Velasco G, Ferrando AA, Puente XS, et al. (1994). "Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues". J. Biol. Chem. 269 (43): 27136–42. PMID 7929457.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.

External links

• The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.