Beta-ketoacyl-acyl-carrier-protein synthase II

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase II (EC 2.3.1.179) is an enzyme that catalyzes the chemical reaction

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]
Beta-ketoacyl-acyl-carrier-protein synthase II
Identifiers
EC number2.3.1.179
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Thus, the two substrates of this enzyme are (Z)-hexadec-11-enoyl-[acyl-carrier-protein] and malonyl-[acyl-carrier-protein], whereas its 3 products are (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein], CO2, and acyl-carrier-protein.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C-acyltransferase (decarboxylating). Other names in common use include KASII, KAS II, FabF, 3-oxoacyl-acyl carrier protein synthase I, and beta-ketoacyl-ACP synthase II. This enzyme participates in fatty acid biosynthesis.

References
    • D'Agnolo G, Rosenfeld IS, Vagelos PR (1975). "Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli". J. Biol. Chem. 250 (14): 5289–94. PMID 237914.
    • Garwin JL, Klages AL, Cronan JE Jr (1980). "Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli". J. Biol. Chem. 255 (24): 11949–56. PMID 7002930.
    • Price AC, Rock CO, White SW (2003). "The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae". J. Bacteriol. 185 (14): 4136–43. doi:10.1128/JB.185.14.4136-4143.2003. PMC 164876. PMID 12837788.
    • Garwin JL, Klages AL, Cronan JE Jr (1980). "Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli Evidence for function in the thermal regulation of fatty acid synthesis". J. Biol. Chem. 255 (8): 3263–5. PMID 6988423.
    • Magnuson K, Carey MR, Cronan JE Jr (1995). "The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene". J. Bacteriol. 177 (12): 3593–5. doi:10.1128/jb.177.12.3593-3595.1995. PMC 177068. PMID 7768872.
    • Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.


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