Aryl-alcohol dehydrogenase

In enzymology, an aryl-alcohol dehydrogenase (EC 1.1.1.90) is an enzyme that catalyzes the chemical reaction

an aromatic alcohol + NAD+ an aromatic aldehyde + NADH + H+
aryl-alcohol dehydrogenase
Identifiers
EC number1.1.1.90
CAS number37250-26-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are aromatic alcohol and NAD+, whereas its 3 products are aromatic aldehyde, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-alcohol:NAD+ oxidoreductase. Other names in common use include p-hydroxybenzyl alcohol dehydrogenase, benzyl alcohol dehydrogenase, and coniferyl alcohol dehydrogenase. This enzyme participates in 5 metabolic pathways: tyrosine metabolism, phenylalanine metabolism, biphenyl degradation, toluene and xylene degradation, and caprolactam degradation.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1F8F.

gollark: Besides, they would have to pay *per unit of data transmitted*, when many have unlimited plans for at least home connections.
gollark: Network effects or something.
gollark: Yes, but they already have internet™ and your mesh thing is worse initially.
gollark: I mean, you could do that, but then nobody uses your thing.
gollark: Paid by whom? You want to charge end users capital?!

References
    • Suhara K, Takemori S, Katagiri M (1969). "The purification and properties of benzylalcohol dehydrogenase from Pseudomonas sp". Arch. Biochem. Biophys. 130 (1): 422–9. doi:10.1016/0003-9861(69)90054-X. PMID 5778658.
    • Yamanaka K; Minoshima R (1984). "Identification and characterization of a nicotinamide adenine dinucleotide-dependent para-hydroxybenzyl alcohol-dehydrogenase from Rhodopseudomonas acidophila M402". Agric. Biol. Chem. 48 (5): 1161–1171. doi:10.1271/bbb1961.48.1161.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.