Aldehyde dehydrogenase 9 family, member A1

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[5][6][7]

ALDH9A1
Identifiers
Aliases	ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1, TMABA-DH, TMABALDH
External IDs	OMIM: 602733 MGI: 1861622 HomoloGene: 55483 GeneCards: ALDH9A1
EC number	1.2.1.3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.1 Start 165,662,216 bp[1] End 165,698,863 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.3 Start 167,349,991 bp[2] End 167,368,532 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • aldehyde dehydrogenase (NAD) activity • oxidoreductase activity • aminobutyraldehyde dehydrogenase activity • 1-pyrroline dehydrogenase activity • 4-trimethylammoniobutyraldehyde dehydrogenase activity • 3-chloroallyl aldehyde dehydrogenase activity • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Cellular component • cytoplasm • extracellular exosome • cytosol Biological process • cellular aldehyde metabolic process • hormone metabolic process • metabolism • oxidation-reduction process • neurotransmitter biosynthetic process • carnitine biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	223	56752
Ensembl	ENSG00000143149	ENSMUSG00000026687
UniProt	P49189	Q9JLJ2
RefSeq (mRNA)	NM_000696 NM_001365774	NM_019993
RefSeq (protein)	NP_000687 NP_001352703	NP_064377
Location (UCSC)	Chr 1: 165.66 – 165.7 Mb	Chr 1: 167.35 – 167.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143149 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026687 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751.
6. Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
7. "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External links

• Human ALDH9A1 genome location and ALDH9A1 gene details page in the UCSC Genome Browser.

Further reading

• Kurys G, Ambroziak W, Pietruszko R (March 1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". The Journal of Biological Chemistry. 264 (8): 4715–21. PMID 2925663.
• Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R (December 1993). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". European Journal of Biochemistry. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
• Kikonyogo A, Pietruszko R (May 1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". The Biochemical Journal. 316 ( Pt 1) (1): 317–24. doi:10.1042/bj3160317. PMC 1217341. PMID 8645224.
• Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
• Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ (March 2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". The Journal of Biological Chemistry. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
• Izaguirre G, Pietruszko R, Cho S, MacKerell A (December 2001). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". Journal of Biomolecular Structure & Dynamics. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142.