ALDH1L2

Aldehyde dehydrogenase 1 family, member L2 also known as ALDH1L2 is an enzyme that in humans is encoded by the ALDH1L2 gene.[5][6] ALDH1L2 is the mitochondrial isoform of a similar enzyme, ALDH1L1, which converts 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide.[7][8]

ALDH1L2
Identifiers
Aliases	ALDH1L2, mtFDH, aldehyde dehydrogenase 1 family member L2
External IDs	OMIM: 613584 MGI: 2444680 HomoloGene: 51942 GeneCards: ALDH1L2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 105,019,784 bp[1] End 105,107,643 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 83,487,450 bp[2] End 83,534,140 bp[2]
Gene ontology Molecular function • hydroxymethyl-, formyl- and related transferase activity • formyltetrahydrofolate dehydrogenase activity • oxidoreductase activity • catalytic activity • aldehyde dehydrogenase (NAD) activity • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Cellular component • extracellular exosome • cytoplasm • mitochondrion • mitochondrial matrix • cell nucleus Biological process • one-carbon metabolic process • biosynthetic process • 10-formyltetrahydrofolate catabolic process • oxidation-reduction process • metabolism • folic acid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	160428	216188
Ensembl	ENSG00000136010	ENSMUSG00000020256
UniProt	Q3SY69	Q8K009
RefSeq (mRNA)	NM_001034173	NM_153543
RefSeq (protein)	NP_001029345	NP_705771
Location (UCSC)	Chr 12: 105.02 – 105.11 Mb	Chr 10: 83.49 – 83.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136010 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020256 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. Ota T, Suzuki Y, Nishikawa T, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
7. Krupenko NI, Dubard ME, Strickland KC, Moxley KM, Oleinik NV, Krupenko SA. "ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase." J Biol Chem. 2010 Jul 23;285(30):23056-63.
8. Strickland KC, Krupenko NI, Dubard ME, Hu CJ, Tsybovsky Y, Krupenko SA. "Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahdyrofolate dehydrogenase." Chem Biol Interact. 2011 May 30;191(1-3):129-36.

External links

• Human ALDH1L2 genome location and ALDH1L2 gene details page in the UCSC Genome Browser.

Further reading

• Strickland KC, Hoeferlin LA, Oleinik NV, et al. (2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.