Alcohol oxidase
In enzymology, an alcohol oxidase (EC 1.1.3.13) is an enzyme that catalyzes the chemical reaction
- a primary alcohol + O2 an aldehyde + H2O2
| alcohol oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Vanillyl-alcohol oxidase oktamer, Penicillium simplicissimum | |||||||||
| Identifiers | |||||||||
| EC number | 1.1.3.13 | ||||||||
| CAS number | 9073-63-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are primary alcohol and O2, whereas its two products are aldehyde and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of the donor with oxygen as the acceptor. The systematic name of this enzyme class is alcohol:oxygen oxidoreductase. This enzyme is also called ethanol oxidase. It employs one cofactor, FAD.
Structural studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1AHU, 1AHV, 1AHZ, 1VAO, 1W1J, 1W1K, 1W1L, 1W1M, and 2VAO.
gollark: Blockchainuously.
gollark: You can prove that you own a particular NFT, but you can't prove that the NFT was originally issued by the actual copyright holder.
gollark: Proof of work.
gollark: We are reading really high apiaristic activity *inside* the main system, actually.
gollark: No, I guess there would be noticeable apiolectromagnetic field leaks.
References
- Janssen FW, Ruelius HW (1968). "Alcohol oxidase, a flavoprotein from several Basidiomycetes species Crystallization by fractional precipitation with polyethylene glycol". Biochim. Biophys. Acta. 151 (2): 330–42. doi:10.1016/0005-2744(68)90100-9. PMID 5636370.
- Nishida A, Ishihara T, Hiroi T (1987). "Studies on enzymes related to lignan biodegradation". Baiomasu Henkan Keikaku Kenkyu. Hokoku: 38–59.
- Suye S (1997). "Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003". Curr. Microbiol. 34 (6): 374–7. doi:10.1007/s002849900198. PMID 9142745.
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