Adrian R. Krainer

Adrian Robert Krainer is a Uruguayan-American biochemist and molecular geneticist.[1] Krainer holds the St. Giles Foundation Professorship at Cold Spring Harbor Laboratory.

Adrian Krainer
Born
Adrian Roberrt Krainer

Montevideo, Uruguay
Alma materColumbia University (BA)
Harvard University (PhD)
AwardsBreakthrough Prize in Life Sciences (2019)
Scientific career
InstitutionsCold Spring Harbor Laboratory
Stony Brook University
ThesisNuclear pre-mRNA splicing in vitro (1986)
InfluencedEwan Birney
Websitewww.cshl.edu/research/faculty-staff/adrian-r-krainer

Early life and education

Krainer was born in Montevideo, Uruguay to a Jewish family of Hungarian and Romanian descent. He has one older brother, who is a chemical engineer. His father did forced labor for two years in a Romanian labor camp (Ferma Alba) during World War II. After the war, his father's original surname, Kreiner changed to Krainer due to a clerical error when he was a refugee in Italy. His parents owned a small leather business in Montevideo. Krainer attended a private bilingual French-Spanish elementary school. He later attended a public school for two years before completing his pre-college education with four years at a private Spanish-Hebrew school. Krainer lived through political unrest during his teenage years, including urban guerrilla and military dictatorship. Krainer received a full scholarship from Columbia University and completed a Bachelor of Arts degree in Biochemistry in 1981. He graduated cum laude and Phi Beta Kappa. In 1986, he earned a Doctor of Philosophy degree in Biochemistry from Harvard University in 1986.[2]

Career and research

From 1986-1989, Krainer conducted postdoctoral research as the first Cold Spring Harbor Fellow at the Cold Spring Harbor Laboratory. Krainer worked as an Assistant Professor from 1989-1990, Associate Professor from 1990-1994, and Professor since 1994. Krainer is a faculty member of the graduate programs in Genetics, Molecular and Cellular Biology, and Molecular Genetics and Microbiology at State University of New York, Stony Brook.[2] Krainer holds the St. Giles Foundation Professorship at Cold Spring Harbor Laboratory.[3] His former students include Ewan Birney.[4][5] Krainer is a co-founder and Director of Stoke Therapeutics, based in Bedford, MA.

Personal Life

Krainer's father and maternal grandparents were Holocaust refugees.[6] He has three children, Emily, Andrew, and Brian.[6][2] His wife, Kate Krainer, is a plant geneticist.[7][8]

Awards and honors

Krainer received a 2019 Breakthrough Prize in Life Sciences for his contributions to the understanding of the RNA gene-splicing process and, in collaboration with fellow Prize Laureate Dr. Frank Bennet of Ionis Pharmaceuticals, the development of medical interventions that target the RNA-splicing process, including Spinraza, which is the first treatment for the genetic disorder Spinal Muscular Atrophy.[6][9] Other honors include: Cold Spring Harbor Fellow (1986-89); Pew Scholar in the Biomedical Sciences (1992-96); National Institute of General Medical Sciences MERIT Award (2012-2022); New York Intellectual Property Law Association Inventor of the Year Award (2017); FE Bennett Award of the American Neurological Association (2017); Herbert & Esther Bennett Brandwein Award in Genetic Research (2018); Bermuda Principles Award (2019); RNA Society Lifetime Achievement Award (2019); Doctor Philosophiae Honoris Causa, Tel Aviv University (2019); International Prize for Translational Neuroscience of the Gertrud Reemstma Foundation/Max Planck Society (2019); Peter Speiser Award in Pharmaceutical Sciences, ETH-Zürich (2019); Ross Prize in Molecular Medicine (2020); Gregor Johann Mendel Medal for Outstanding Achievements in Science (2020), Brno, Czech Republic; Takeda and New York Academy of Sciences Innovators in Science Senior Scientist Award in Rare Diseases (2020); Fellow of the American Academy of Arts & Sciences (2016); Fellow of the National Academy of Inventors (2018); Member of the National Academy of Medicine (2019). In 2020, Krainer was elected to the National Academy of Sciences[10].

gollark: Also, people will just use Actually Additions, probably, for power.
gollark: If they make a giant NC reactor, what will they spend power on?
gollark: Gollark's Law: Without encouragement to do otherwise, people will initially go for the easy thing.
gollark: Realistically everyone will use Ender IO.
gollark: How is it centered around NC, anywæy?

References
  1. Adrian R. Krainer publications from Europe PubMed Central
  2. Maestrejuan, Andrea R. (September 9, 1997). "ADRIAN R. KRAINER" (PDF). sciencehistory.org. Chemical Heritage Foundation. Retrieved October 16, 2018.
  3. "Adrian R. Krainer - Cold Spring Harbor Laboratory". cshl.edu. Cold Spring Harbor Laboratory. Retrieved October 16, 2018.
  4. Al-Khalili, Jim (2013). "The Life Scientific, Ewan Birney". bbc.co.uk. BBC.
  5. Birney, E.; Kumar, S.; Krainer, A. (1992). "A putative homolog of U2AF65 in S. Cerevisiae". Nucleic Acids Research. 20 (17): 4663. doi:10.1093/nar/20.17.4663. PMC 334203. PMID 1408772.
  6. "Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Adrian R. Krainer". breakthroughprize.org. Retrieved August 8, 2020.
  7. s.r.o, Via Aurea. "Adrian Krainer, the Scientist Who Brought Hope to Thousands of Children, Shared his Experience With Students". www.ceitec.eu. Retrieved August 8, 2020.
  8. s.r.o, Via Aurea. "Life after PhD with Adrian and Kate Krainer". www.ceitec.eu. Retrieved August 8, 2020.
  9. "Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – C. Frank Bennett". breakthroughprize.org. Retrieved August 8, 2020.
  10. "2020 NAS Election". www.nasonline.org. Retrieved May 1, 2020.
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