Adipokine

The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue. The first adipokine to be discovered was leptin in 1994.[1] Since that time, hundreds of adipokines have been discovered.[2]

Members include:

In addition, interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown to be associated with excessive body weight.[7]

Notes
  1. Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413–420. doi:10.1002/biof.185. PMID 22038756.
  2. Lehr S, Hartwig S, Sell H (2012). "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". Proteomics: Clinical Applications. 6 (1–2): 91–101. doi:10.1002/prca.201100052. PMID 22213627.
  3. Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009;34(4):142-54.
  4. MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161
  5. Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054
  6. Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150
  7. Sharabiani, MT; Vermeulen R; Scoccianti C; Hosnijeh FS; Minelli L; Sacerdote C; Palli D; Krogh V; Tumino R; Chiodini P; Panico S; Vineis P. (May 2011). "Immunologic profile of excessive body weight". Biomarkers. 16 (3): 243–51. doi:10.3109/1354750X.2010.547948. PMID 21506696.
gollark: Assuming these "military police" had higher standards than regular police now, would that still be the case if you scaled that system up to match all the ones they're replacing?
gollark: Members of parliament?
gollark: Whatever the cause actually is, I'm not sure there really is a hugely consistent one.
gollark: Destroying random people's stuff is unlikely to make anyone sympathetic to the cause.
gollark: We live in a society.
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