APOBEC3D

Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.[3][4]

APOBEC3D
Identifiers
Aliases	APOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D
External IDs	OMIM: 609900 HomoloGene: 122788 GeneCards: APOBEC3D
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 39,021,113 bp[1] End 39,033,277 bp[1]
Gene ontology Molecular function • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines • zinc ion binding • catalytic activity • hydrolase activity • metal ion binding • RNA binding • cytidine deaminase activity Cellular component • cytoplasm • P-body • cell nucleus Biological process • negative regulation of transposition • innate immune system • defense response to virus • DNA cytosine deamination • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate • immune system process • cytidine deamination • cytidine to uridine editing • DNA demethylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140564	n/a
Ensembl	ENSG00000243811	n/a
UniProt	B2CML4	n/a
RefSeq (mRNA)	NM_152426 NM_001363781	n/a
RefSeq (protein)	NP_689639 NP_001350710	n/a
Location (UCSC)	Chr 22: 39.02 – 39.03 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.[4]

References

1. GRCh38: Ensembl release 89: ENSG00000243811 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
4. "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".

External links

• Human APOBEC3D genome location and APOBEC3D gene details page in the UCSC Genome Browser.

Further reading

• Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
• Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins". Nat. Rev. Immunol. 4 (11): 868–77. doi:10.1038/nri1489. PMID 15516966.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mariani R, Chen D, Schröfelbauer B, et al. (2003). "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif". Cell. 114 (1): 21–31. doi:10.1016/S0092-8674(03)00515-4. PMID 12859895.
• Sawyer SL, Emerman M, Malik HS (2006). "Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G". PLoS Biol. 2 (9): E275. doi:10.1371/journal.pbio.0020275. PMC 479043. PMID 15269786.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Dang Y, Wang X, Esselman WJ, Zheng YH (2006). "Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family". J. Virol. 80 (21): 10522–33. doi:10.1128/JVI.01123-06. PMC 1641744. PMID 16920826.
• Kinomoto M, Kanno T, Shimura M, et al. (2007). "All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition". Nucleic Acids Res. 35 (9): 2955–64. doi:10.1093/nar/gkm181. PMC 1888823. PMID 17439959.