AKR1

Aldo-keto reductase family 1 (AKR1) is a family of aldo-keto reductase enzymes that is involved in steroid metabolism.[1] It includes the AKR1C and AKR1D subgroups, which respectively consist of AKR1C1–AKR1C4 and AKR1D1.[1] Together with short-chain dehydrogenase/reductases (SDRs), these enzymes catalyze oxidoreductions, act on the C3, C5, C11, C17 and C20 positions of steroids, and function as 3α-HSD, 3β-HSDs, 5β-reductases, 11β-HSDs, 17β-HSDs, and 20α-HSDs, respectively.[1] The AKR1C enzymes act as 3-, 17- and 20-ketosteroid reductases, while AKR1D1 acts as the sole 5β-reductase in humans.[1]

AKR1C1, a member of the AKR1 family.

Members

AKR1A1; AKR1B1; AKR1B10; AKR1C1; AKR1C2; AKR1C3; AKR1C4; AKR1D1; Others

gollark: Some trees contain power distribution for them.
gollark: Only very buggy sensor nodes would do things if you danced.
gollark: They do not. You would need to use the API properly, not just randomly dance.
gollark: Airbending is... very targeted use of local weather management systems?
gollark: Airbending, obviously.

See also

References
  1. Rižner TL, Penning TM (2014). "Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism". Steroids. 79: 49–63. doi:10.1016/j.steroids.2013.10.012. PMC 3870468. PMID 24189185.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.