5-amino-6-(5-phosphoribosylamino)uracil reductase

In enzymology, a 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) is an enzyme that catalyzes the chemical reaction

5-amino-6-(5-phosphoribitylamino)uracil + NADP+ 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+
5-amino-6-(5-phosphoribosylamino)uracil reductase
Identifiers
EC number1.1.1.193
CAS number69020-28-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 5-amino-6-(5-phosphoribitylamino)uracil and NADP+, whereas its 3 products are 5-amino-6-(5-phosphoribosylamino)uracil, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase. This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase. This enzyme participates in riboflavin metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 2AZN, 2B3Z, 2D5N, 2G6V, 2HXV, 2O7P, and 2OBC.

gollark: But I don't think lyric had a PoC of the issue.
gollark: LyricLy actually did try and report it on the github.
gollark: Oh, i named an account "administrator" and that works too!
gollark: Unintended features, probably.
gollark: Also this: https://pronouny.xyz/u/%5Bdeleted%20user%5D

References
    • Burrows RB, Brown GM (1978). "Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin". J. Bacteriol. 136 (2): 657–67. PMC 218591. PMID 30756.


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