21-hydroxysteroid dehydrogenase (NAD+)

In enzymology, a 21-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.150) is an enzyme that catalyzes the chemical reaction

pregnan-21-ol + NAD+ pregnan-21-al + NADH + H+
21-hydroxysteroid dehydrogenase (NAD+)
Identifiers
EC number1.1.1.150
CAS number37250-75-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are pregnan-21-ol and NAD+, whereas its 3 products are pregnan-21-al, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NAD+ 21-oxidoreductase. This enzyme is also called 21-hydroxysteroid dehydrogenase (NAD+).

References

    • Monder C, White A (1965). "The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases". J. Biol. Chem. 240: 71–7. PMID 14253469.


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