2-dehydropantolactone reductase (A-specific)
In enzymology, a 2-dehydropantolactone reductase (A-specific) (EC 1.1.1.168) is an enzyme that catalyzes the chemical reaction
- (R)-pantolactone + NADP+ 2-dehydropantolactone + NADPH + H+
| 2-dehydropantolactone reductase (A-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.168 | ||||||||
| CAS number | 37211-75-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (R)-pantolactone and NADP+, whereas its 3 products are 2-dehydropantolactone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP+ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).
References
- King HL Jr, Dyar RE, Wilken DR (Aug 10, 1974). "Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 249 (15): 4689–4695. PMID 4603075.
- Wilken DR, King HL Jr, Dyar RE (March 25, 1975). "Ketopantoic acid and ketopantoyl lactone reductases: Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate". J. Biol. Chem. 250 (6): 2311–2314. PMID 234966.
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