2-dehydropantoate 2-reductase

In enzymology, a 2-dehydropantoate 2-reductase (EC 1.1.1.169) is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NADP+ 2-dehydropantoate + NADPH + H+
2-dehydropantoate 2-reductase
Identifiers
EC number1.1.1.169
CAS number37211-74-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are (R)-pantoate and NADP+, whereas its 3 products are 2-dehydropantoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP.

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References
    • King HL Jr, Dyar RE, Wilken DR (Aug 10, 1974). "Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase". J. Biol. Chem. 249 (15): 4689–4695. PMID 4603075.


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