1,5-anhydro-D-fructose reductase
In enzymology, a 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) is an enzyme that catalyzes the chemical reaction
- 1,5-anhydro-D-glucitol + NADP+ 1,5-anhydro-D-fructose + NADPH + H+
1,5-anhydro-D-fructose reductase | |||||||||
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Identifiers | |||||||||
EC number | 1.1.1.263 | ||||||||
CAS number | 206138-19-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are 1,5-anhydro-D-glucitol and NADP+, whereas its 3 products are 1,5-anhydro-D-fructose, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP+ oxidoreductase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GLX.
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References
- Sakuma M, Kametani S, Akanuma H (January 1998). "Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose". Journal of Biochemistry. 123 (1): 189–93. doi:10.1093/oxfordjournals.jbchem.a021909. PMID 9504428.
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