Unspecific peroxygenase

Unspecific peroxygenase (EC 1.11.2.1, aromatic peroxygenase, mushroom peroxygenase, haloperoxidase-peroxygenase, Agrocybe aegerita peroxidase) is an enzyme with systematic name substrate:hydrogen peroxide oxidoreductase (RH-hydroxylating or -epoxidising).[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

RH + H2O2 ROH + H2O
Unspecific peroxygenase
Identifiers
EC number1.11.2.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Unspecific peroxygenase is a heme-thiolate protein comparable to Cytochrome P450 in the ability to catalyze a variety of P450 reactions (hence "unspecific"), but forms a unique, solely fungal, protein family of extracellular enzymes.

References
  1. Ullrich R, Nüske J, Scheibner K, Spantzel J, Hofrichter M (August 2004). "Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes". Applied and Environmental Microbiology. 70 (8): 4575–81. doi:10.1128/AEM.70.8.4575-4581.2004. PMC 492325. PMID 15294788.
  2. Ullrich R, Hofrichter M (November 2005). "The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene". FEBS Letters. 579 (27): 6247–50. doi:10.1016/j.febslet.2005.10.014. PMID 16253244.
  3. Anh DH, Ullrich R, Benndorf D, Svatos A, Muck A, Hofrichter M (September 2007). "The coprophilous mushroom Coprinus radians secretes a haloperoxidase that catalyzes aromatic peroxygenation". Applied and Environmental Microbiology. 73 (17): 5477–85. doi:10.1128/AEM.00026-07. PMC 2042081. PMID 17601809.
  4. Ullrich R, Dolge C, Kluge M, Hofrichter M (December 2008). "Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita". FEBS Letters. 582 (29): 4100–6. doi:10.1016/j.febslet.2008.11.006. PMID 19022254.
  5. Aranda E, Kinne M, Kluge M, Ullrich R, Hofrichter M (April 2009). "Conversion of dibenzothiophene by the mushrooms Agrocybe aegerita and Coprinellus radians and their extracellular peroxygenases". Applied Microbiology and Biotechnology. 82 (6): 1057–66. doi:10.1007/s00253-008-1778-6. PMID 19039585.
  6. Kinne M, Poraj-Kobielska M, Aranda E, Ullrich R, Hammel KE, Scheibner K, Hofrichter M (June 2009). "Regioselective preparation of 5-hydroxypropranolol and 4'-hydroxydiclofenac with a fungal peroxygenase". Bioorganic & Medicinal Chemistry Letters. 19 (11): 3085–7. doi:10.1016/j.bmcl.2009.04.015. PMID 19394224.
  7. Kluge M, Ullrich R, Dolge C, Scheibner K, Hofrichter M (January 2009). "Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation". Applied Microbiology and Biotechnology. 81 (6): 1071–6. doi:10.1007/s00253-008-1704-y. PMID 18815784.
  8. Kinne M, Poraj-Kobielska M, Ralph SA, Ullrich R, Hofrichter M, Hammel KE (October 2009). "Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase". The Journal of Biological Chemistry. 284 (43): 29343–9. doi:10.1074/jbc.M109.040857. PMC 2785565. PMID 19713216.
  9. Pecyna MJ, Ullrich R, Bittner B, Clemens A, Scheibner K, Schubert R, Hofrichter M (October 2009). "Molecular characterization of aromatic peroxygenase from Agrocybe aegerita". Applied Microbiology and Biotechnology. 84 (5): 885–97. doi:10.1007/s00253-009-2000-1. PMID 19434406.
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