GPX6

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.[5][6]

GPX6
Identifiers
AliasesGPX6, GPX5p, GPXP3, GPx-6, GSHPx-6, dJ1186N24, dJ1186N24.1, glutathione peroxidase 6
External IDsOMIM: 607913 MGI: 1922762 HomoloGene: 130008 GeneCards: GPX6
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.1Start28,503,296 bp[1]
End28,528,215 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

257202

75512

Ensembl

ENSG00000281185
ENSG00000198704

ENSMUSG00000004341

UniProt

P59796

Q91WR8

RefSeq (mRNA)

NM_182701

NM_145451

RefSeq (protein)

NP_874360

NP_663426

Location (UCSC)Chr 6: 28.5 – 28.53 MbChr 13: 21.31 – 21.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Expression of this gene is restricted to embryos and adult olfactory epithelium.[5]

References

  1. ENSG00000198704 GRCh38: Ensembl release 89: ENSG00000281185, ENSG00000198704 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004341 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: glutathione peroxidase 6 (olfactory)".
  6. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. doi:10.1126/science.1083516. PMID 12775843.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.