Fetal trimethadione syndrome
Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others[1]) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.[2]
| Fetal trimethadione syndrome | |
|---|---|
| Other names | German syndrome |
 | |
| Condition is caused by Trimethadione (and paramethadione) | |
Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,[3] meaning it affects less than 200,000 individuals in the United States.[4]
The fetal loss rate while using trimethadione has been reported to be as high as 87%.[5]
Presentation
Fetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione.[2][6]
- Cranial and facial abnormalities which include; microcephaly, midfacial flattening, V-shaped eyebrows and a short nose
- Cardiovascular abnormalities
- Absent kidney and ureter
- Meningocele, a birth defect of the spine
- Omphalocele, a birth defect where portions of the abdominal contents project into the umbilical cord
- A delay in mental and physical development
Diagnosis
Treatment
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References
- Additional names include trimethadione embryopathy and trimethadione syndrome.
- Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007
- Fetal trimethadione syndrome on the ORD website. Retrieved January 2007
- NIH's Office of Rare Diseases Archived 2009-02-06 at the Wayback Machine Retrieved January 2007
- Teratology and Drug Use During Pregnancy Retrieved January 2007
- The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome Retrieved January 2007
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