Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
In enzymology, a trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) is an enzyme that catalyzes the chemical reaction
- trans-1,2-dihydrobenzene-1,2-diol + NADP+ catechol + NADPH + H+
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.20 | ||||||||
| CAS number | 37255-32-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are trans-1,2-dihydrobenzene-1,2-diol and NADP+, whereas its three products are catechol, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called dihydrodiol dehydrogenase. This enzyme participates in metabolism of xenobiotics by cytochrome p450.
Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2HDJ, 2IPJ, 2O48, 2O4U, and 2POQ.
References
- AYENGAR PK, HAYAISHI O, NAKAJIMA M, TOMIDA I (1959). "Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol". Biochim. Biophys. Acta. 33 (1): 111–9. doi:10.1016/0006-3002(59)90504-9. PMID 13651190.