Sulfadoxine
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.[1]
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| ECHA InfoCard | 100.017.732  |
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| Formula | C12H14N4O4S |
| Molar mass | 310.33 g·mol−1 |
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| Melting point | 190 to 194 °C (374 to 381 °F) |
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It is also used to prevent malaria[2] but due to high levels of resistance, this use is becoming less common.[3]
It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
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See also
References
- Medical Treatment - Sulphadoxine and Pyrimethamine Archived 2007-12-28 at the Wayback Machine.
- https://www.who.int/malaria/areas/preventive_therapies/pregnancy/en/
- Matondo SI, Temba GS, Kavishe AA, et al. (2014). "High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania". Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
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