Spermosin

Spermosin (EC 3.4.21.99) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolyses arginyl bonds, preferably with Pro in the P2 position
Spermosin
Identifiers
EC number3.4.21.99
CAS number89925-67-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the ascidian (Prochordate) Halocynthia roretzi.

References

  1. Sawada H, Yokosawa H, Ishii S (March 1984). "Purification and characterization of two types of trypsin-like enzymes from sperm of the ascidian (Prochordata) Halocynthia roretzi. Evidence for the presence of spermosin, a novel acrosin-like enzyme". The Journal of Biological Chemistry. 259 (5): 2900–4. PMID 6365918.
  2. Sawada H, Yokosawa H, Someno T, Saino T, Ishii S (September 1984). "Evidence for the participation of two sperm proteases, spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme activities and fertilization". Developmental Biology. 105 (1): 246–9. doi:10.1016/0012-1606(84)90281-1. PMID 6381175.
  3. Sawada H, Iwasaki K, Kihara-Negishi F, Ariga H, Yokosawa H (May 1996). "Localization, expression, and the role in fertilization of spermosin, an ascidian sperm trypsin-like protease". Biochemical and Biophysical Research Communications. 222 (2): 499–504. doi:10.1006/bbrc.1996.0773. PMID 8670234.
  4. Sawada H, Someno T (October 1996). "Substrate specificity of ascidian sperm trypsin-like proteases, spermosin and acrosin". Molecular Reproduction and Development. 45 (2): 240–3. doi:10.1002/(SICI)1098-2795(199610)45:2<240::AID-MRD18>3.0.CO;2-4. PMID 8914083.
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