RAM-378

RAM-378 [1](7,8-Dihydro-14-hydroxy-N-phenethylnormorphine) is an opioid analgesic. It is the N-phenethyl derivative of hydromorphinol.

RAM-378

Identifiers
IUPAC name 3,6,14-trihydroxy-4,5α-epoxy-17-(2-phenylethyl)morphinan
CAS Number	4778-96-5^Y
PubChem CID	5492826
ChemSpider	4591168^Y
CompTox Dashboard (EPA)	DTXSID70963936
Chemical and physical data
Formula	C24H27NO4
Molar mass	393.483 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3CCC6=CC=CC=C6)[C@H]([C@H]1O)OC5=C(C=C4)O)O
InChI InChI=1S/C24H27NO4/c26-17-7-6-16-14-19-24(28)10-8-18(27)22-23(24,20(16)21(17)29-22)11-13-25(19)12-9-15-4-2-1-3-5-15/h1-7,18-19,22,26-28H,8-14H2/t18-,19+,22-,23-,24+/m0/s1 Key:GAHRZWMAHDWVCL-VKJMTUIMSA-N
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See also

• 14-Cinnamoyloxycodeinone
• 14-Phenylpropoxymetopon
• 7-PET
• N-Phenethylnormorphine
• N-Phenethyl-14-ethoxymetopon
• Phenomorphan
• Ro4-1539

References

1. doi: 10.1371/journal.pone.0099231 Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity