Poly(adp-ribose) polymerase family member 14

PARP14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GOY, 3Q6Z, 3Q71, 3SE2, 3SMI, 3SMJ, 3VFQ, 4ABK, 4ABL, 4D86, 4F1L, 4F1Q, 4PY4
Identifiers
Aliases	PARP14, ARTD8, BAL2, PARP-14, pART8, poly(ADP-ribose) polymerase family member 14
External IDs	OMIM: 610028 MGI: 1919489 HomoloGene: 19697 GeneCards: PARP14
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	122,730,840 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	35,871,544 bp[2]
Gene ontology
Molecular function	• transferase activity; • transferase activity, transferring glycosyl groups; • RNA binding; • GO:0001948 protein binding; • NAD+ binding; • NAD+ ADP-ribosyltransferase activity; • enzyme binding; • protein ADP-ribosylase activity;
Cellular component	• membrane; • cell nucleus; • cytosol; • cytoplasm;
Biological process	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • protein poly-ADP-ribosylation; • protein ADP-ribosylation; • negative regulation of gene expression; • positive regulation of tyrosine phosphorylation of STAT protein; • negative regulation of tyrosine phosphorylation of STAT protein; • negative regulation of interferon-gamma-mediated signaling pathway; • positive regulation of interleukin-4-mediated signaling pathway; • immune system process; • innate immune system; • protein mono-ADP-ribosylation;
	Sources:Amigo / QuickGO
Orthologs
	54625
	547253
	ENSG00000173193
	ENSMUSG00000034422
	Q460N5; Q8N546
	Q2EMV9
	NM_017554
	NM_001039530
	NP_060024; NP_060024.2
	NP_001034619
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene. [5]

Function

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).

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References

GRCh38: Ensembl release 89: ENSG00000173193 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034422 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Poly(ADP-ribose) polymerase family member 14". Retrieved 2016-03-02.

DNA repair
Excision repair	Base excision repair/AP site DNA glycosylase Uracil-DNA glycosylase Poly ADP ribose polymerase Nucleotide excision repair/ERCC XPA XPB XPC XPD/ERCC2 XPE/DDB1 XPF/DDB1 XPG/ERCC5 ERCC1 RPA RAD23A RAD23B Excinuclease DNA mismatch repair MLH1 MSH2
Other forms of repair	Transcription-coupled repair ERCC6 ERCC8 Homology directed repair Non-homologous end joining Ku Microhomology-mediated end joining Postreplication repair Photolyase CRY1 CRY2
Other/ungrouped proteins	Ogt PcrA Proliferating Cell Nuclear Antigen Homologous recombination RecA/RAD51 Sgs1 Slx4
Regulation	SOS box SOS response
Other/ungrouped	8-Oxoguanine Adaptive response Meiotic recombination checkpoint RecF pathway DNA helicase: BLM WRN FANC proteins: core protein complex FANCA FANCB FANCC FANCE FANCF FANCG FANCL FANCM FANCD1 FANCD2 FANCI FANCJ FANCN

Poly(adp-ribose) polymerase family member 14

Function

References

Further reading