Penicillin amidase

In enzymology, a penicillin amidase (EC 3.5.1.11) is an enzyme that catalyzes the chemical reaction

penicillin + H2O a carboxylate + 6-aminopenicillanate
penicillin amidase
Identifiers
EC number3.5.1.11
CAS number9014-06-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are penicillin and H2O, whereas its two products are carboxylate and 6-aminopenicillanate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is penicillin amidohydrolase. Other names in common use include penicillin acylase, benzylpenicillin acylase, novozym 217, semacylase, alpha-acylamino-beta-lactam acylhydrolase, and ampicillin acylase. This enzyme participates in penicillin and cephalosporin biosynthesis.

Structural studies

As of late 2007, 34 structures have been solved for this class of enzymes, with PDB accession codes 1AI4, 1AI5, 1AI6, 1AI7, 1AJN, 1AJP, 1AJQ, 1CP9, 1E3A, 1FXH, 1FXV, 1GK0, 1GK1, 1GK9, 1GKF, 1GM7, 1GM8, 1GM9, 1H2G, 1JX9, 1K5Q, 1K5S, 1K7D, 1KEC, 1PNK, 1PNL, 1PNM, 2ADV, 2AE3, 2AE4, 2AE5, 2IWM, 2PVA, and 3PVA.

gollark: Shiny big projects get tons of maintainers, random less shiny ones can still be important and often don't.
gollark: Bold of you to assume that.
gollark: SQLite is probably one of the most popular libraries ever, but it's also very well-maintained, so not that.
gollark: Hmm, what things are there which are very widely used, mostly ignored, and require maintenance... I could look at some arch package update logs.
gollark: I thought that had lots of contributors.

References

    • Sakaguchi K, Murao S (1950). "A preliminary report on a new enzyme, "penicillin-amidase"". J. Agric. Chem. Soc. Jpn. 23: 411.


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