Pancreatic endopeptidase E

Pancreatic endopeptidase E (EC 3.4.21.70, cholesterol-binding proteinase, proteinase E, cholesterol-binding serine proteinase, pancreatic protease E, pancreatic proteinase E, cholesterol-binding pancreatic proteinase, CBPP, pancreas E proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Preferential cleavage: Ala-. Does not hydrolyse elastin
Pancreatic endopeptidase E
Identifiers
EC number3.4.21.70
CAS number68073-27-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is peptidase of family S1 (trypsin family) from pancreatic juice.

References

  1. Mallory PA, Travis J (February 1975). "Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase". Biochemistry. 14 (4): 722–30. doi:10.1021/bi00675a012. PMID 234742.
  2. Shen WF, Fletcher TS, Largman C (June 1987). "Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (12): 3447–52. doi:10.1021/bi00386a030. PMID 3477287.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.