Mucin 7

Mucin-7 is a protein that in humans is encoded by the MUC7 gene.[3][4] In animals, the MUC7 gene is found in most placental mammals, but not marsupials.[5]

For the MUC-7 conference, see Message Understanding Conference.

MUC7
Identifiers
Aliases	MUC7, MG2, mucin 7, secreted
External IDs	OMIM: 158375 HomoloGene: 133350 GeneCards: MUC7
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 70,430,492 bp[1] End 70,482,997 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • Golgi lumen • extracellular region • extracellular exosome • cell membrane Biological process • O-glycan processing • stimulatory C-type lectin receptor signaling pathway • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4589	n/a
Ensembl	ENSG00000171195	n/a
UniProt	Q8TAX7	n/a
RefSeq (mRNA)	NM_152291 NM_001145006 NM_001145007	n/a
RefSeq (protein)	NP_001138478 NP_001138479 NP_689504	n/a
Location (UCSC)	Chr 4: 70.43 – 70.48 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Human variations

Humans carry either a five or six tandem repeat version of the gene. In other primates, the number of repeats found is 4-5 for gorillas, 5 for chimpanzees, 6-7 for orangutans, 8-10 for macaques, 10-11 for baboons and 11-12 for green monkeys.[5]

Some modern people from Sub-Saharan Africa were found to carry a five tandem repeat variation of the MUC7 gene that is highly divergent from other, modern humans. The coalescence age for the human variations of the MUC7 gene is estimated to be around 4.5 million years ago, which predates the human-Neanderthal split. Neanderthals and Denisovans also carry variants that are much closer to those of other, modern humans; thus, researchers postulate that this divergent Sub-Saharan variant most likely introgressed from a currently yet-unknown archaic human ghost population.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000171195 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Bobek LA, Liu J, Sait SN, Shows TB, Bobek YA, Levine MJ (February 1996). "Structure and chromosomal localization of the human salivary mucin gene, MUC7". Genomics. 31 (3): 277–82. doi:10.1006/geno.1996.0049. PMID 8838308.
4. "Entrez Gene: MUC7 mucin 7, secreted".
5. Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O (August 2016). "Recent evolution of the salivary mucin MUC7". Scientific Reports. 6: 31791. doi:10.1038/srep31791. PMC 4997351. PMID 27558399. This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
6. Xu D, Pavlidis P, Taskent RO, Alachiotis N, Flanagan C, DeGiorgio M, Blekhman R, Ruhl S, Gokcumen O (October 2017). "Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation". Molecular Biology and Evolution. 34 (10): 2704–2715. doi:10.1093/molbev/msx206. PMC 5850612. PMID 28957509. This article contains quotations from this source, which is available under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

Further reading

• Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). "Structure and biosynthesis of human salivary mucins". Acta Biochimica Polonica. 47 (4): 1067–79. doi:10.18388/abp.2000_3960. PMID 11996097.
• Bobek LA, Tsai H, Biesbrock AR, Levine MJ (September 1993). "Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)". The Journal of Biological Chemistry. 268 (27): 20563–9. PMID 7690757.
• Troxler RF, Iontcheva I, Oppenheim FG, Nunes DP, Offner GD (October 1997). "Molecular characterization of a major high molecular weight mucin from human sublingual gland". Glycobiology. 7 (7): 965–73. doi:10.1093/glycob/7.7.965. PMID 9363439.
• Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ (April 1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry. 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.
• Kirkbride HJ, Bolscher JG, Nazmi K, Vinall LE, Nash MW, Moss FM, Mitchell DM, Swallow DM (May 2001). "Genetic polymorphism of MUC7: allele frequencies and association with asthma". European Journal of Human Genetics. 9 (5): 347–54. doi:10.1038/sj.ejhg.5200642. PMID 11378823.
• Guo JM, Zhang Y, Cheng L, Iwasaki H, Wang H, Kubota T, Tachibana K, Narimatsu H (July 2002). "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12". FEBS Letters. 524 (1–3): 211–8. doi:10.1016/S0014-5793(02)03007-7. PMID 12135769.
• Cheng L, Tachibana K, Zhang Y, Guo J, Kahori Tachibana K, Kameyama A, Wang H, Hiruma T, Iwasaki H, Togayachi A, Kudo T, Narimatsu H (November 2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10". FEBS Letters. 531 (2): 115–21. doi:10.1016/S0014-5793(02)03399-9. PMID 12417297.
• Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R, Aceves-Luna E, González-Begné M (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students". Archives of Medical Research. 33 (5): 499–505. doi:10.1016/S0188-4409(02)00395-8. PMID 12459324.
• Wang H, Tachibana K, Zhang Y, Iwasaki H, Kameyama A, Cheng L, Guo J, Hiruma T, Togayachi A, Kudo T, Kikuchi N, Narimatsu H (January 2003). "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Biochemical and Biophysical Research Communications. 300 (3): 738–44. doi:10.1016/S0006-291X(02)02908-X. PMID 12507512.
• Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF (June 2003). "MG2 and lactoferrin form a heterotypic complex in salivary secretions". Journal of Dental Research. 82 (6): 471–5. doi:10.1177/154405910308200613. PMID 12766201.
• Ge J, Catt DM, Gregory RL (November 2004). "Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen". Infection and Immunity. 72 (11): 6748–52. doi:10.1128/IAI.72.11.6748-6752.2004. PMC 523000. PMID 15501816.
• Grys TE, Siegel MB, Lathem WW, Welch RA (March 2005). "The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells". Infection and Immunity. 73 (3): 1295–303. doi:10.1128/IAI.73.3.1295-1303.2005. PMC 1064933. PMID 15731026.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD (October 2005). "Two-hybrid analysis of human salivary mucin MUC7 interactions". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1746 (1): 65–72. doi:10.1016/j.bbamcr.2005.08.007. PMID 16203048.
• Li S, Intini G, Bobek LA (July 2006). "Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo". American Journal of Respiratory Cell and Molecular Biology. 35 (1): 95–102. doi:10.1165/rcmb.2005-0305OC. PMC 2658701. PMID 16514118.