Lanatoside C
Lanatoside C (or isolanid) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally[1] or by the intravenous route.[2] It is marketed in a number of countries and is also available in generic form.[3] Its main indications are rapid response atrial fibrilation and paroxysmal supraventricular tachycardia, two common types of arrhythmia.
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Other names | [6-[6-[6-[[12,14-dihydroxy- 10,13-dimethyl- 17-(5-oxo-2H-furan-3-yl)- 1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradecahydrocyclopenta[a]phenanthren- 3-yl]oxy]- 4-hydroxy- 2-methyloxan- 3-yl]oxy- 4-hydroxy- 2-methyloxan-3-yl]oxy- 2-methyl- 3-[3,4,5-trihydroxy- 6-(hydroxymethyl)oxan-2-yl]oxyoxan- 4-yl] acetate |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral, intravenous |
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ECHA InfoCard | 100.037.754 |
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Formula | C49H76O20 |
Molar mass | 985.127 g·mol−1 |
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It is found in Digitalis lanata.[4]
Chemistry
The substance is composed of four monosaccharides (glucose, 3-acetyldigitoxose and two digitoxoses) and an aglycon named digoxigenin.[5]
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References
- Lypka A, Lazowski J (September 1979). "[Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]" [Comparative study of blood serum concentrations of digoxin and lanatoside C after single oral administration]. Wiadomosci Lekarskie (in Polish). 32 (18): 1277–81. PMID 506267.
- Tàmmaro AE, Baldoli C (January 1967). "[On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]" [On some immediate effects of the intravenous administration of desacetyl-lanatoside C in aged subjects]. La Clinica Terapeutica (in Italian). 40 (2): 157–61. PMID 5600177.
- "Lanatoside C". International Drug Names. Drugs.com.
- Ikeda Y, Fujii Y, Yamazaki M (June 1992). "Determination of Lanatoside C and Digoxin in Digitalis lanata by HPLC and its Application to Analysis of the Fermented Leaf Powder". Journal of Natural Products. 55 (6): 748–52. doi:10.1021/np50084a007.
- Desai UR (2005). "Cardiac Glycosides". VCU School of Pharmacy.
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