L-proline amide hydrolase

L-proline amide hydrolase (EC 3.5.1.101, S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase, LaaA, L-amino acid amidase) is an enzyme with systematic name (S)-piperidine-2-carboxamide amidohydrolase.[1] This enzyme catalyses the following chemical reaction

(1) (S)-piperidine-2-carboxamide + H2O (S)-piperidine-2-carboxylic acid + NH3
(2) L-prolinamide + H2O L-proline + NH3
L-proline amide hydrolase
Identifiers
EC number3.5.1.101
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

References

  1. Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (April 2004). "S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase". European Journal of Biochemistry. 271 (8): 1465–75. doi:10.1111/j.1432-1033.2004.04056.x. PMID 15066172.
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