Kallikrein 13
Kallikrein 13 (EC 3.4.21.119, KLK13, kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin-converting enzyme, PRECE, proteinase P) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg- pair in the N-terminus, to yield mature renin
| Kallikrein 13 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.119 | ||||||||
| CAS number | 342900-44-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme belongs in peptidase family S1A.
References
- Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K (December 1990). "Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis". The Journal of Biological Chemistry. 265 (34): 21027–31. PMID 2250008.
- Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K (April 1990). "A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization". The Journal of Biological Chemistry. 265 (11): 5930–3. PMID 2180937.
- Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K (January 1998). "Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1382 (1): 55–64. doi:10.1016/s0167-4838(97)00144-1. PMID 9507064.
- Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K (March 2006). "Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice". The Journal of Biological Chemistry. 281 (12): 7968–76. doi:10.1074/jbc.m507705200. PMID 16423834.
External links
- Kallikrein+13 at the US National Library of Medicine Medical Subject Headings (MeSH)
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