Isotonitazene

Isotonitazene is a benzimidazole derived opioid analgesic drug related to etonitazene[1][2], which has been sold as a designer drug[1].[3] It has only around half the potency of etonitazene in animal studies,[1][4][5][6][7][8][9] but it is likely less potent in humans as was seen with Etonitazene (1000x as potent as Morphine in animal models yet only 60x as potent in humans)[1].

Isotonitazene
Clinical data
Routes of
administration		oral, nasal spray, e-vape
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC23H30N4O3
Molar mass410.518 g·mol−1
3D model (JSmol)

Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5x more potent than hydromorphone and slightly more potent than fentanyl.[1][10]

Side effects

Side effects of benzimidazole derived opioids are expected to be similar to those of fentanyl, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.

Isotonitazene has been detected in multiple fatalities in the US since August 2019.[11]

The US Drug Enforcement Administration issued a notice of intent to publish a temporary order to schedule isotonitazene in Schedule I of the Controlled Substances Act.[12]

gollark: Otherwise no.
gollark: i.e. bite/kill.
gollark: They do if you kill them as a direct result of your action.
gollark: Maybe you could trade for 3d ones.
gollark: Or focus intensely for one hour.

See also

References
  1. Blanckaert, Peter; Cannaert, Annelies; Uytfanghe, Katleen Van; Hulpia, Fabian; Deconinck, Eric; Calenbergh, Serge Van; Stove, Christophe (2019). "Report on a novel emerging class of highly potent benzimidazole NPS opioids: chemical and in vitro functional characterization of isotonitazene". Drug Testing and Analysis. n/a (n/a). doi:10.1002/dta.2738. ISSN 1942-7611.
  2. Casy, A. F.; Wright, J. (October 1966). "Ionisation constants and partition coefficients of some analgesically active 2-benzylbenzimidazole derivatives and related compounds". Journal of Pharmacy and Pharmacology. 18 (10): 677–683. doi:10.1111/j.2042-7158.1966.tb07782.x. ISSN 2042-7158. PMID 4382076.
  3. https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.2738 Power M. 40 Americans Are Dying Every Month From Taking this New, Legal Opioid. 2020 Mar 13. Vice.com
  4. Hunger A, Kebrle J, Rossi A, Hoffmann K (October 1957). "[Synthesis of analgesically active benzimidazole derivatives with basic substitutions]" [Synthesis of analgesically active benzimidazole derivatives with basic substitutions]. Experientia. 13 (10): 400–1. doi:10.1007/BF02161116. PMID 13473817.
  5. Rossi A, Hunger A, Kebrle J, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen. IV. Die Kondensation von o-Phenylendiamin mit α-Aryl- und γ-Aryl-acetessigester" [Benzimidazole derivatives and related heterocycles IV. The condensation of o-phenylenediamine with α-aryl and γ-aryl-acetoacetate]. Helvetica Chimica Acta (in German). 43 (4): 1046–1056. doi:10.1002/hlca.19600430413.
  6. Rossi A, Hunger A, Kebrle J, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen V. Die Kondensation von o-Phenylendiamin mit aliphatischen und alicyclischen β-Ketoestern" [Benzimidazole derivatives and related heterocycles V. The condensation of o-phenylenediamine with aliphatic and alicyclic β-keto esters]. Helvetica Chimica Acta (in German). 43 (5): 1298–1313. doi:10.1002/hlca.19600430515.
  7. Rossi A, Hunger A, Kebrle J, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen VI. Synthese von Phenyl-[1-aminoalkyl-benzimidazolyl-(2)]-essigsäure-estern und -amiden" [Benzimidazole derivatives and related Heterocycles VI. Synthesis of phenyl-[1-aminoalkyl-benzimidazolyl-(2)]-acetic acid esters and amides]. Helvetica Chimica Acta (in German). 43 (6): 1727–1733. doi:10.1002/hlca.19600430634.
  8. Rossi A, Hunger A, Kebrle J, Hoffmann K (1961). "Benzimidazol-Derivate und verwandte Heterocyclen VII. Synthese neuer 2-Amino-benzimidazole" [Benzimidazole Derivatives and related Heterocycles VII. Synthesis of new 2-amino-benzimidazole]. Helvetica Chimica Acta (in German). 44 (5): 1273–1282. doi:10.1002/hlca.19610440513.
  9. Gross F, Turrian H (October 1957). "Über Benzimidazolderivate mit starker analgetischer Wirkung" [Benzimidazole derivatives with strong analgesic effects]. Experientia. 13 (10): 401–3. doi:10.1007/BF02161117. PMID 13473818.
  10. Vandeputte, Marthe M.; Cannaert, Annelies; Stove, Christophe P. (July 2020). "In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances". Archives of Toxicology. doi:10.1007/s00204-020-02855-7. ISSN 1432-0738. PMID 32734307.
  11. Krotulski, Alex J.; Papsun, Donna M.; Kacinko, Sherri L.; Logan, Barry K. (February 2020). "Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework". Journal of Analytical Toxicology. doi:10.1093/jat/bkaa016. PMID 32091095.
  12. "Schedules of Controlled Substances: Temporary Placement of Isotonitazene in Schedule I". Federal Register. 18 June 2020.
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