Imidazolonepropionase
In enzymology, an imidazolonepropionase (EC 3.5.2.7) is an enzyme that catalyzes the chemical reaction
- (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O N-formimidoyl-L-glutamate + H+
| imidazolonepropionase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 imidazolonepropionase dimer, Agrobacterium fabrum | |||||||||
| Identifiers | |||||||||
| EC number | 3.5.2.7 | ||||||||
| CAS number | 9024-91-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate and H2O, whereas its two products are N-formimidoyl-L-glutamate and H+.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase. Other names in common use include 4(5)-imidazolone-5(4)-propionic acid hydrolase, and imidazolone propionic acid hydrolase. This enzyme participates in histidine metabolism.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2BB0, 2G3F, 2GOK, 2OOF, 2PUZ, and 2Q09.
References
- Rao DR; Greenberg DM (1961). "Studies on the enzymic decomposition of urocanic acid. IV Purification and properties of 4(5)-imidazolone-5(4)-propionic acid hydrolase". J. Biol. Chem. 236: 1758–1763. PMID 13739526.
- Snyder SH, Silva OL, Kies MW (1961). "The mammalian metabolism of L-histidine. IV. Purification and properties of imidazolone propionic acid hydrolase". J. Biol. Chem. 236: 2996–2998. PMID 13914653.