Hippurate hydrolase

In enzymology, a hippurate hydrolase (EC 3.5.1.32) is an enzyme that catalyzes the chemical reaction

hippurate + H2O benzoate + glycine
hippurate hydrolase
Identifiers
EC number3.5.1.32
CAS number37278-43-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are hippurate and H2O, whereas its two products are benzoate and glycine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-benzoylamino-acid amidohydrolase. This enzyme participates in phenylalanine metabolism.

References

    • Tsoi E, Akmal S, Geerts L, Jeffery B, Nicolaides KH (2006). "Sonographic measurement of cervical length and fetal fibronectin testing in threatened preterm labor". Ultrasound Obstet. Gynecol. 27 (4): 368–72. doi:10.1002/uog.2723. PMID 16526097.
    • Tsoi E, Akmal S, Geerts L, Jeffery B, Nicolaides KH (2006). "Sonographic measurement of cervical length and fetal fibronectin testing in threatened preterm labor". Ultrasound Obstet. Gynecol. 27 (4): 368–72. doi:10.1002/uog.2723. PMID 16526097.
    • Rohrmann K, Niemann R, Buddecke E (1985). "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". Eur. J. Biochem. 148 (3): 463–9. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.