Health of Frédéric Chopin

Frédéric Chopin's disease and the reason for his premature death at age 39 were frequently debated for over 150 years. Although he was diagnosed with and treated for tuberculosis throughout his lifetime, a number of alternative diagnoses have been suggested since his death in 1849. A comprehensive review of the possible causes of Chopin's illness was published in 2011.[1] A visual examination of Chopin's heart, for which permission was finally given in 2017, indicated the likely cause of death as pericarditis, caused by tuberculosis. This has been disputed by pathologists who say that a visual examination alone cannot confirm such a disease.[2]

Chopin on His Deathbed, by Kwiatkowski, 1849, commissioned by Jane Stirling. Chopin sits in bed, in the presence of (from left) Aleksander Jełowicki, Chopin's sister Ludwika, Marcelina Czartoryska, Wojciech Grzymała, Kwiatkowski.

Case history
Chopin's death mask, created by Auguste Clésinger on 17 October 1849 (photographs from the collection of Jack Gibbons)

From childhood, Frédéric Chopin was sickly and under medical care. He showed intolerance to fatty foods, especially pork – these caused stomach aches, diarrhea and weight loss. Later he endeavored to avoid such symptoms with diet; he obtained substantial improvement with ingredients such as honey and oat bran. Chopin attained a height of 170 centimetres (5 ft 7 in) — the 25th percentile; and as an adult weighed under 45 kilograms (99 lb) — below the 3rd percentile.[3]

Chopin is known to have had no facial hair at the age of 22; as he wrote in the winter of 1832, he grew sideburns on only one side of his face.[4] In 1826 he was sick for six months, suffering from enlarged cervical lymph nodes and severe headaches. In 1830, a chronic cold caused nasal swelling which prompted him to cancel planned concerts in Vienna.

In 1831, while in Paris, the 21-year-old Chopin had his first episode of hemoptysis (coughing up of blood). In 1835, he suffered a severe two-month bout of laryngitis and bronchitis, and the resulting interruption in his correspondence with Warsaw gave rise to gossip that he had died.[5]

In his early youth, he treated himself with belladonna. In the final decade of his life, he treated the coughing fits from which he had suffered his entire life with a blend of sugar and opium. Chopin coughed up an abundant amount of mucus, particularly around 10 a.m.[6] He occasionally drank alcohol, sometimes smoked and – as some authors noted – suffered the consequences of inhaling others' smoke while enjoying the company of his Parisian friends.[4] In the last year of his life, he endured diarrheas, caused either by cor pulmonale or by exocrine pancreatic insufficiency (see below).

On 17 October 1849, at 2 a.m., after a sudden coughing fit, Chopin died at the age of 39. His physician, Jean Cruveilhier, confirmed his death by holding a mirror to Chopin's mouth and by illuminating his pupils with light from a candle. Pursuant to Chopin's will, Dr. Cruveilhier, a renowned professor of pathology, carried out an autopsy. The postmortem findings were also communicated to Chopin's sister Ludwika, Adolphe Gutmann and Jane Stirling. The postmortem report was destroyed either in the Paris fire of 1871 or during World War II. The death certificate stated the cause of Chopin's death as tuberculosis of the lungs and larynx. However, Wojciech Grzymała, in a letter to Auguste Leo dated October 1849, wrote that the autopsy had not confirmed tubercular pulmonary changes and that his actual disease was unknown to contemporary medicine.[7]

Physicians

It is uncertain how many physicians Chopin had; various authors have given the number as 14,[8] 31[9] or "nearly 50".[10] In addition, the composer had friendly relations with other physicians, who may also have occasionally provided him with assistance.[9]

In Warsaw, Chopin's physicians were Jan Fryderyk Wilhelm Malcz, Franciszek Girardot and Fryderyk Adolf Roemer. In Vienna, Chopin was provided medical care by Johann Malfatti. Chopin's physicians in Paris included Aleksander Hofman, Jean-Jacques Molin, André François Cauviere, Jan Matuszyński, Adam Raciborski, Pierre Gaubert, Gustave Papet and Coste. During his 1848 stay in London – Mallan and James Clark. In Paris, in 1848–49, he was treated by Léon Simon, Fraenkel, David Koreff, Louis and Roth.[4] Chopin's last physician was Jean Cruveilhier.

Family history

Little is known about the health of Frédéric's father, Nicolas Chopin, who lived to the age of 73 and suffered several times from respiratory infections. The composer's mother had no chronic illness and reached the age of 87.

Of Frédéric's three sisters, Izabela died at age 70 and had no illnesses; Ludwika suffered from recurrent respiratory infections and died at 47; the youngest, Emilia, was of frail health from earliest childhood. Emilia suffered from recurrent coughs and dyspnea; at 11 she began having hemorrhages from the upper gastrointestinal tract, and she died of a massive hemorrhage at 14.

Tuberculosis

Chopin was diagnosed with tuberculosis and treated for it in accordance with contemporary practice, including bloodletting and purging. Tuberculosis was listed on his death certificate, despite the alleged absence of typical organ changes. Critics of alternative hypotheses about Chopin's disease point out the abundant evidence for tuberculosis.[11][12][13] Chronic coughs and hemoptysis are common symptoms of tuberculosis; complications may include both pericarditis, causing right-heart insufficiency, and bronchiectasis, manifesting in productive cough and respiratory failure.

A 20-year history of hemoptysis is rare in tuberculosis but not impossible. Similarly, cavernous tuberculosis is rare in childhood, but it cannot be excluded in the case of Emilia Chopin. Frédéric could have contracted tuberculosis from his younger sister.[14]

A monograph on historic methods of treating tuberculosis has discussed individual treatments on the example of Chopin, since his history well illustrates views on treating tuberculosis in the mid-19th century.[15]

Autopsy and results

Attempts were made to gain permission to extract a small amount of tissue from Chopin's heart in order to test it for a range of specific conditions. Dr. Michael Witt of Warsaw's Institute of Molecular and Cell Biology made such a request in 2008, but permission was denied by the Polish government.[16] In 2017, a visual inspection was at last performed on Chopin's alcohol-preserved heart, under the direction of Professor Witt of the Polish Academy of Sciences. The heart remained in alcohol, and the container was not opened, so it could not be touched or sampled. Closer inspection suggested that a rare case of pericarditis, caused by complications from chronic tuberculosis, was the likely cause of Chopin's death.[17]

Other hypotheses
Cast of Chopin's left hand

A number of alternative hypotheses about the cause of Chopin's death flourished over the years.

The hypothesis that Chopin suffered from cystic fibrosis was first presented by O’Shea in 1987.[18] Chopin possibly was sexually active from early adulthood, but left no descendants. Some authors considered this evidence for infertility, which favoured the cystic fibrosis hypothesis.[19]

A hypothesis of alpha 1-antitrypsin deficiency was proposed by Kuzemko in 1994.[4]

Mitral stenosis was a possible, if unlikely, cause for the artist's complaints and was discussed by Kubba and Young in 1998.[20] The most important argument against this hypothesis is the absence of evidence that Chopin suffered from rheumatic fever in childhood, which is the most common cause of mitral valve stenosis.

Kubba and Young pointed out a number of other conceivable, if unlikely, diagnoses, besides cystic fibrosis and alpha 1-antitrypsin deficiency: eosinophilic granulomatosis with polyangiitis, allergic bronchopulmonary aspergillosis, hypogammaglobulinemia, idiopathic pulmonary haemosiderosis, lung abscesses, and pulmonary arteriovenous malformations.[20]

Mental health

Chopin's biographers have often touched on the subject of depression, but the topic has rarely been broached by psychiatrists. One of the few studies of Chopin's mental condition is a 1920 work by Bronislaw Onuf-Onufrowicz. The author cited biographers concerning Chopin's character and psyche and pointed out some symptoms that might indicate a manic-depressive disorder or dementia praecox (now termed schizophrenia), but he emphasized the absence of evidence for severe psychosis and the fact that single symptoms may only suggest a predisposition to such mental illnesses.[21]

gollark: Are they just 0 and 1?
gollark: What do you WANT me to DO, exaCTLY?
gollark: ++delete <@319753218592866315> for antigollarkic heresy too
gollark: · · ·
gollark: ++delete <@341618941317349376> for antigollarkic heresy

References
  1. Lagerberg, Steven. "Chopin's Heart - The Quest to Identify the Mysterious Illness of the World's Most Beloved Composer." Lagerberg, 2011, ISBN 1-4564-0296-X.
  2. https://www.bbc.com/news/magazine-29915863
  3. O'Shea JG (1987). "Was Frédéric Chopin's illness actually cystic fibrosis?". The Medical Journal of Australia. 147 (11–12): 586–9. PMID 3320707.
  4. Kuzemko, JA (1994). "Chopin's illnesses". Journal of the Royal Society of Medicine. 87 (12): 769–72. PMC 1294992. PMID 7853308.
  5. John O'Shea: Music & Medicine: Medical Profiles of Great Composers. London: Dent, 1990, p. 144. ISBN 0-460-86106-9
  6. John O'Shea: Music & Medicine: Medical Profiles of Great Composers. London: Dent, 1990, p. 143. ISBN 0-460-86106-9
  7. John O'Shea: Music & Medicine: Medical Profiles of Great Composers. London: Dent, 1990, p. 149. ISBN 0-460-86106-9
  8. K. Barry, "Chopin and His Fourteen Doctors", Sydney Austral. Med. Publish. Co., 1934, cited from Sielużycki, 1976.
  9. Sielużycki C (1976). "Lekarze Chopina". Archiwum Historii Medycyny. 39 (3): 305–32.
  10. E. Stocki (1956), "Zapomniani lekarze-przyjaciele Fryderyka Chopina", Polski Tygodnik Lekarski, 24, pp. 1102-4 (1956). Cited from Sielużycki, 1976.
  11. Cheng TO (1998). "Chopin's illness". Chest. 114 (2): 654–5. doi:10.1378/chest.114.2.654-a. PMID 9726766.
  12. Margolis, ML (1998). "The long suffering of Frederic Chopin, revisited". Chest. 114 (2): 655. doi:10.1378/chest.114.2.655. PMID 9726767.
  13. Carter ER (1998). "Chopin's malady". Chest. 114 (2): 655–6. doi:10.1378/chest.114.2.655-a. PMID 9726768.
  14. O'Shea, John M. (1990). Music & medicine: medical profiles of great composers. London: Dent. pp. 142–3. ISBN 0-460-86106-9.
  15. Long, Esmond R. (1956). A History of the Therapy of Tuberculosis and the Case of Frederic Chopin. Lawrence, Kansas: University Press of Kansas. OCLC 14617261.
  16. Robin McKie, "Row over plan to DNA test Chopin's heart". The Guardian, 27 July 2008. Retrieved 3 November 2014
  17. McKie, Robin (4 November 2017). "Examination of Chopin's pickled heart solves riddle of his early death". The Guardian. Retrieved 5 November 2017.
  18. O'Shea, JG (1987). "Was Frédéric Chopin's illness actually cystic fibrosis?". The Medical Journal of Australia. 147 (11–12): 586–9. PMID 3320707.
  19. Majka, L; Goździk, J; Witt, M (2003). "Cystic fibrosis--a probable cause of Frédéric Chopin's suffering and death". Journal of applied genetics. 44 (1): 77–84. PMID 12590184.
  20. Kubba, AK; Young, M (1998). "The long suffering of Frederic Chopin". Chest. 113 (1): 210–6. doi:10.1378/chest.113.1.210. PMID 9440592.
  21. Onuf-Onufrowicz, Bronislaw (1920). "Frederick Chopin's Mental Makeup". Dementia Praecox Studies. 3 (1–2): 199–204.
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