HLA-Cw7
HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw7 is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus.[1] Cw7 and Cw*07 are almost synonymous in meaning. Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7.
HLA-Cw7 | ||||||||||||||||
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(MHC Class I, C cell surface antigen) | ||||||||||||||||
About | ||||||||||||||||
Protein | transmembrane receptor/ligand | |||||||||||||||
Structure | αβ heterodimer | |||||||||||||||
Subunits | HLA-Cw*07--, β2-microglobulin | |||||||||||||||
Older names | - | |||||||||||||||
Subtypes | ||||||||||||||||
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Alleles link-out to IMGT/HLA database at EBI |
Serotype
Cw*07 | Cw7 | Sample |
allele | % | size (N) |
*0701 | 74 | 304 |
*0702 | 68 | 976 |
Distribution
Study population | Freq. (in %)[3] |
---|---|
Cameroon Pygmy Baka | 25.0 |
Ireland South | 21.2 |
German Essen | 20.9 |
Cameroon Sawa | 19.2 |
Ireland Northern | 18.7 |
France West | 18.1 |
Kenya | 17.8 |
Burkina Faso Fulani | 17.4 |
Australia New South Wales | 17.3 |
France South East | 17.3 |
Morocco 'Berber' Nador Me… | 16.7 |
Sudanese | 16.5 |
United Kingdom Caucasians | 16.1 |
Uganda Kampala | 16.0 |
Brazil | 15.6 |
USA Caucasian (2) | 15.5 |
Kenya Nandi | 15.2 |
Pakistan Baloch | 15.2 |
Burkina Faso Rimaibe | 14.9 |
Finland | 14.4 |
Czech Republic | 14.2 |
Swiss Geneva | 13.6 |
South Africa Natal Tamil | 13.5 |
Cameroon Bamileke | 13.0 |
India Khandesh Pawra | 13.0 |
Cameroon Beti | 12.9 |
Tunisia | 12.6 |
India New Delhi | 12.5 |
Saudi Arabia Guraiat and … | 12.3 |
Turkey | 12.3 |
Zambia Lusaka | 12.2 |
Kenya Luo | 11.7 |
Burkina Faso Mossi | 11.3 |
South Korea (1) | 11.1 |
Spain Eastern Andalusia | 11.0 |
USA Hispanic | 10.9 |
Lebanon | 10.8 |
India Tamil Nadu Nadar | 10.7 |
Zimbabwe Harare Shona | 10.6 |
Russia Arkhangelsk Pomors | 10.0 |
Georgia Tibilisi Georgian… | 9.8 |
Mexico Zaptotec Oaxaca | 9.7 |
Israel Arab Druse | 9.0 |
Senegal Niokholo Mandenka | 8.7 |
USA North American Native… | 8.6 |
Pakistan Sindhi | 8.3 |
India North Delhi | 8.0 |
Iran Baloch | 7.8 |
Thailand | 7.7 |
Singapore Riau Malay | 7.5 |
India West Coast Parsis | 7.0 |
Georgia Tibilisi Kurds | 6.9 |
Pakistan Kalash | 6.5 |
Mali Bandiagara | 6.2 |
Pakistan Burusho | 5.6 |
Pakistan Karachi Parsi | 5.5 |
Pakistan Pathan | 5.5 |
Russia Murmansk Saomi | 4.0 |
Singapore Javanese Indone… | 4.0 |
India Mumbai Marathas | 3.7 |
Australia Indig. Cape Yor… | 3.4 |
Pakistan Brahui | 3.4 |
India West Bhils | 3.0 |
China North Han | 2.9 |
Jordan Amman | 2.8 |
China Inner Mongolia | 2.5 |
Italy North Pavia | 2.5 |
Russia Nenets | 2.4 |
China Qinghai Hui | 2.3 |
Australia Indig. Groote E… | 2.1 |
Russia Tuva (2) | 2.0 |
USA Hawaii Okinawa | 1.9 |
USA Asian | 1.8 |
China South Han | 1.6 |
China Beijing | 1.5 |
Papua New Guinea Wanigela | 1.4 |
Allele frequencies presented, only |
Study population | Freq. (in %)[3] |
---|---|
Venezuela Sierra de Perij… | 71.4 |
PNG New Britain Rabaul | 57.1 |
Mexico Mixtec Oaxaca | 33.3 |
China Yunnan Lisu | 32.9 |
Taiwan Taroko | 31.8 |
China Yunnan Nu | 30.7 |
Venezuela Perja Mountain … | 30.3 |
PNG Madang | 30.2 |
Mexico Zaptotec Oaxaca | 28.4 |
Taiwan Tsou | 27.5 |
Mexico Mixe Oaxaca | 26.4 |
Russia Arkhangelsk Pomors | 26.0 |
Ch. Guangdong Meizhou H… | 25.8 |
Pakistan Burusho | 25.5 |
USA South Dakota Lakota S… | 24.4 |
Russia Nenets | 23.8 |
USA New Mexico Canoncito … | 23.2 |
China South Han | 20.8 |
Brazil Terena | 20.2 |
China Guangzhou | 19.9 |
USA Asian | 19.5 |
Ireland Northern | 18.6 |
Swiss Geneva | 18.2 |
Taiwan Bunun | 17.8 |
Ireland South | 17.4 |
Singapore Javanese Indone… | 17.0 |
Philippines Ivatan | 16.0 |
Taiwan Rukai | 16.0 |
Australia New South Wales | 15.8 |
Finland | 15.6 |
USA South Texas Hispanics | 15.6 |
Pakistan Sindhi | 15.5 |
United Kingdom Caucasians | 15.5 |
Saudi Arabia Guraiat and … | 15.2 |
Cameroon Pygmy Baka | 15.0 |
India Tamil Nadu Nadar | 14.8 |
Japan Central | 14.6 |
Russia Murmansk Saomi | 14.0 |
USA Hawaii Okinawa | 13.8 |
China Beijing | 13.6 |
China Tibetan | 13.3 |
China Qinghai Hui | 13.2 |
Thailand | 13.0 |
USA North American Native… | 12.8 |
China Inner Mongolia | 12.7 |
Japan (3) | 12.7 |
Pakistan Brahui | 12.5 |
PNG Wanigela | 12.5 |
USA Caucasian pop2 | 12.5 |
USA Hispanic | 12.4 |
Czech Republic | 12.3 |
China North Han | 11.9 |
Taiwan Paiwan | 11.8 |
China Wuhan | 11.6 |
Cameroon Sawa | 11.5 |
Taiwan Siraya | 10.8 |
Taiwan Ami | 10.7 |
New Caledonia | 10.0 |
India North Delhi | 9.9 |
Australia Indig. Cape Yor… | 9.6 |
Pakistan Pathan | 9.5 |
France West | 9.4 |
Iran Baloch | 9.4 |
South Africa Natal Tamil | 9.4 |
German Essen | 9.1 |
Taiwan Puyuma | 9.0 |
India New Delhi | 8.9 |
Pakistan Kalash | 8.7 |
India Mumbai Marathas | 8.6 |
Russia Tuva pop 2 | 8.6 |
South Korea (3) | 8.3 |
American Samoa | 8.0 |
Brazil | 8.0 |
USA African American | 8.0 |
France South East | 7.2 |
Cameroon Bamileke | 7.1 |
India West Bhils | 7.0 |
Australia Indig. Yuendumu | 6.8 |
Cameroon Beti | 6.6 |
Georgia Tibilisi Georgian… | 6.5 |
Uganda Kampala | 6.1 |
Turkey | 6.0 |
Spain Eastern Andalusia | 5.5 |
PNG Wosera | 5.4 |
Mali Bandiagara | 4.7 |
Zimbabwe Harare Shona | 4.6 |
Mexico Chihuahua State Ta… | 4.5 |
Pakistan Baloch | 4.5 |
Kenya | 4.4 |
Zambia Lusaka | 4.4 |
Lebanon | 4.1 |
Israel Arab Druse | 4.0 |
Kenya Luo | 3.8 |
Tunisia | 3.6 |
PNG Eastern Highlands Gor… | 3.5 |
Sudanese | 3.5 |
Georgia Tibilisi Kurds | 3.4 |
Morocco 'Berber' Nador Me… | 3.2 |
England London Ashkenazi … | 2.9 |
Allele frequencies presented, only |
gollark: Then why does it *also* have this bizarre custom cryptographic stuff?
gollark: So *why* did you not just *use TLS*?
gollark: Which is probably bad then.
gollark: It's certainly... very creative.
gollark: Ah. So. If I understand this right, it goes through every authorized API key, tries to decrypt the message with the hash of that, and if one matches it takes that as the key to use for the connection?
References
- Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- Allele Query Form IMGT/HLA - European Bioinformatics Institute
- Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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