HLA-Cw4

HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw4 is determined by the antibody recognition of α⁴ subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning. Cw4 is more common in Southeast Europe, where it is part of the Cw4-B35 haplotype.

HLA-Cw4
(MHC Class I, C cell surface antigen)
HLA-Cw4
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-Cw*04--, β2-microglobulin
Older names	-
Subtypes
Subtype allele Available structures Cw4 *0401 {{{cNick2}}} *04{{{cAllele2}}} {{{cNick3}}} *04{{{cAllele3}}} {{{cNick4}}} *04{{{cAllele4}}}
Rare alleles
Subtype allele Available structures Cw403 *0403 {{{rnick2}}} *04{{{rallele2}}} {{{rnick3}}} *04{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

Serotype

Cw4 recognition of some HLA Cw*04 gene products[2]

Cw*04	Cw4	Cw403	Cw6	Sample
allele	%	%	%	size (N)
*0401	98	0	0	736
*0403	37	5	17	25

Alleles

HLA Cw*0401 frequencies

Study population	Freq.  (in %)[3]
Mexico Mixe Oaxaca	37.8
Mexico Mixtec Oaxaca	37.3
USA N. Mexico Canoncito N…	31.7
Mexico Zaptotec Oaxaca	30.6
Iran Baloch	28.6
Australia Indig. Cape Yor…	27.5
Australia Indig.Yuendumu	26.8
Australia Indig. Groote E…	25.3
Lebanon	24.3
Israel Arab Druse	22.5
Georgia Tibilisi Kurds	22.4
Brazil Terena	22.3
Georgia Tibilisi Georgian…	22.0
India Tamil Nadu Nadar	21.3
Mali Bandiagara	21.3
Taiwan Ami	20.9
Papua New Guinea Wanigela	20.8
USA African Americans pop…	19.6
Senegal Niokholo Mandenka	19.5
Cameroon Beti	18.7
Indig. Australian Kimberl…	17.9
Papua New Guinea Wosera	17.0
Italy North pop 1	16.7
New Caledonia	16.7
Morocco Nador Metalsa (be…	15.9
Portugal Centre pop 2	15.8
Cameroon Sawa	15.4
India Mumbai Marathas	15.4
Iran Tehran	15.4
USA Hispanic	15.0
PNG West Schrader Ranges	14.8
Zimbabwe Harare Shona	14.8
Swiss Geneva	14.5
Zambia Lusaka	14.4
Uganda Kampala	14.1
Brazil	13.7
Sudanese	13.5
France West	13.4
Tibetan	13.3
Finland	13.3
Kenya Luo	13.2
Cameroon Bamileke	13.0
Philippines Ivatan	13.0
Kenya	12.9
Singapore Riau Malay	12.2
India North Delhi	11.7
Tunisia	11.6
Kenya Nandi	11.5
Russia Tuva pop 2	11.5
Taiwan Bunun	11.4
USA Caucasian pop2	11.1
India West Coast Parsis	11.0
China Qinghai Hui	10.9
Czech Republic	10.8
India New Delhi	10.7
Spain Eastern Andalusia	10.4
UK Caucasians	10.1
Cameroon Pygmy Baka	10.0
China Beijing	10.0
Jordan Amman	10.0
Singapore Javanese	10.0
Papua New Guinea Madang	9.5
Saudi Arabia Guraiat and …	9.5
Australia New South Wales	9.4
USA Alaska Yupik Natives	9.3
Bulgaria Gipsy	9.1
Mex. Chihuahua Tarahumara	9.1
German Essen	9.0
France South East	8.9
Taiwan Paiwan	8.8
China Inner Mongolia	8.3
Ireland Northern	8.3
Venezuela Perija Yucpa	8.3
South Korea (1)	8.2
China North Han	7.6
USA South Dakota Lakota S…	7.4
Taiwan Atayal	7.1
India West Bhils	7.0
PNG Karimui Plateau	6.9
Taiwan Siraya	6.9
Taiwan Thao	6.7
Japan (5)	6.5
Thailand	6.0
China Guangzhou	5.6
USA Asian	5.6
Ireland South	5.4
PNG Eastern Highlands Gor…	4.7
Japan Central	4.6
Spain Eastern Andalusia G…	4.5
China South Han	4.4
South Africa Natal Tamil	4.2
American Samoa	4.0
Taiwan Saisiat	3.9
Papua New Guinea New Brit…	3.6
Taiwan Minnan pop 1	3.4
USA Hawaii Okinawa	3.3
China Guangdong Meizhou H…	3.0
India Khandesh Pawra	3.0
Taiwan Puyuma	3.0
Allele frequencies presented, only

HLA Cw*0403 frequencies

Study population	Freq.  (in %)[3]
PNG West Schrader Ranges	45.9
Taiwan Tao	40.0
PMG Eastern Highlands Gor…	34.9
PNG Madang	25.0
PNG Wanigela	16.0
Australia Indig. Cape Yor…	15.7
Australia Indig. Yuendumu	15.1
Australia Indig. Groote E…	12.3
Taiwan Puyuma	12.0
PNG Karimui Plateau	11.9
Taiwan Pazeh	11.8
Taiwan Thao	11.7
New Caledonia	11.1
Singapore Riau Malay	9.8
PNG New Britain Rabaul	8.9
PNG Wosera	8.0
Singapore Javanese	7.0
Taiwan Rukai	7.0
Taiwan Bunun	6.4
American Samoa	6.0
Thailand	5.3
Philippines Ivatan	5.0
Taiwan Siraya	4.9
Taiwan Tsou	4.9
Australia Indig. Kimberly	3.6
Taiwan Atayal	3.3
South Africa Natal Tamil	3.1
Taiwan Ami	2.6
China South Han	2.1
USA Asian	2.0
Taiwan Hakka	1.8
China Qinghai Hui	1.4
Iran Tehran	1.3
China Guangdong Meizhou H…	1.0
China Inner Mongolia	1.0
India West Coast Parsis	1.0
Taiwan Minnan pop 1	1.0
Taiwan Paiwan	1.0
India New Delhi	0.9
Russia Tuva	0.9
China Tibetan	0.6
Allele frequencies presented, only

References

1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
3. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.