Efavirenz/lamivudine/tenofovir

Efavirenz/lamivudine/tenofovir (EFV/3TC/TDF), sold under the brand name Telura among others, is a fixed-dose combination medication for the treatment of HIV/AIDS.[1] It combines efavirenz, lamivudine, and tenofovir disoproxil.[1] As of 2019, it is listed by the World Health Organization as an alternative first line option to dolutegravir/lamivudine/tenofovir.[2] It is taken by mouth.[1]

Efavirenz/lamivudine/tenofovir
Combination of
EfavirenzNon-nucleoside reverse transcriptase inhibitor
LamivudineNucleoside reverse transcriptase inhibitor
Tenofovir disoproxilNucleoside reverse transcriptase inhibitor
Clinical data
Trade namesTelura, Symfi, Symfi Lo
Other namesEFV/3TC/TDF
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa618028
Pregnancy
category
  • US: N (Not classified yet)
    Routes of
    administration    		By mouth
    ATC code
    Legal status
    Legal status
    • US: ℞-only
    • In general: ℞ (Prescription only)

    Side effects can include joint pain, sleepiness, headaches, depression, trouble sleeping, and itchiness.[1] Severe side effects may include depression, psychosis, or osteonecrosis.[1] In those with a history of epilepsy, it may increase the frequency of seizures.[1] Greater care should also be taken in those with kidney problems.[1] It is unclear if use during pregnancy is safe.[1][3]

    It is on the World Health Organization's List of Essential Medicines.[4] The combination received tentative approval in the United States in 2014,[5] and was granted approval in February 2018.[6][7] Its availability and importance is supported by Medecins Sans Frontieres.[1]

    It is available as a generic medication.[8]

    References
    1. "Efavirenz + lamivudine + tenofovir disoproxil fumarate (Addition) -- Adults". World Health Organization (WHO).
    2. World Health Organization (July 2019). Policy brief: update of recommendations on first- and second-line antiretroviral regimens. World Health Organization. hdl:10665/325892. WHO/CDS/HIV/19.15. License: CC BY-NC-SA 3.0 IGO.
    3. "Telura" (PDF). Mylan.in. 2014. Retrieved 13 December 2017.
    4. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    5. "HIV/AIDS History of Approvals - HIV/AIDS Historical Time Line 2010 - 2015". U.S. Food and Drug Administration (FDA). Retrieved 13 December 2017.
    6. "Drug Approval Package: Symfi Lo (efavirenz, lamivudine and tenofovir disoproxil fumarate)". accessdata.fda.gov. 9 October 2018. Retrieved 15 August 2020.
    7. "Drug Approval Package: Symfi (efavirenz, lamivudine and tenofovir disoproxil fumarate)". accessdata.fda.gov. 24 November 2018. Retrieved 15 August 2020.
    8. "Drug Approval Package: Efavirenz, Lamivudine and Tenofovir disoproxil". U.S. Food and Drug Administration (FDA). 26 November 2018. Retrieved 15 August 2020.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.