Debi Prasad Sarkar

Debi Prasad Sarkar (born 15 January 1958) is an Indian biochemist, immunologist and virologist. He was the head of biochemistry department at the University of Delhi and served as the Director of IISER Mohali from 2017 to 2019. His contract as Director, IISER Mohali was terminated by MHRD following complaints of financial irregularities. Ever since, he resumed his Professorship at the parent institute, University of Delhi.[1][2] He is renowned for his researches on Sendai virus and developing reconstituted viral envelopes.[3] He is an elected fellow of Indian Academy of Sciences,[4] National Academy of Sciences, India[5] and Indian National Science Academy.[6] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1998, for his contributions to biological sciences.[7]

Debi Prasad Sarkar
Born (1958-01-15) 15 January 1958
India
NationalityIndian
Alma mater
Known forDevelopment of reconstituted Sendai viral envelopes
Awards1998 Shanti Swarup Bhatnagar Prize
2005 SBC M. Sreenivasaya Memorial Award
Scientific career
Fields
Institutions

Biography

Debi Prasad Sarkar, born on 15 January 1958, graduated (honours) in chemistry in 1978 and obtained a master's degree in biochemistry in 1980, both from Banaras Hindu University.[8] His career started as a research assistant at the University of Delhi in 1985, working on Liposomes as immunomodulators and drug delivery using Liposomes and he secured a PhD degree for his thesis, Immunogenicity of carbohydrate determinants mediated through Liposomes: Liposome-mediated drug delivery from the University of Delhi in 1986. His post-doctoral studies were at the National Cancer Institute of the National Institutes of Health where he spent two years (1986–88) as visiting fellow and returned to Delhi University to take up the position of a lecturer of biochemistry. He stayed at the university for the rest of his academic career, holding various positions as the senior lecturer (1993–96) and reader (1996–2008), to superannuate as a professor in 2023.[8]

Legacy

Sarkar's researches on Sendai virus is known to have resulted in the development of reconstituted viral envelopes containing only the fusion protein[9] and this is reported to have assisted in a more efficient gene delivery in therapeutic use.[10] Along with Vijay Kumar, he demonstrated for the first time that HBx protein stimulated Mitogen-activated signaling cascades in living animals.[11] He continued his researches while working as an academic and holds patents for his inventions.[12] Some of the inventions have resulted in Patent Cooperation Treaties (PCT) earning royalties for the university. He has also participated in clinical trials on behalf of the university, including a preclinical study with a Gunn rat model, in collaboration with National Research Development Corporation and AECOM.[6] He has published his research findings in a number of articles[13][note 1] and has delivered featured lectures on his work.[14] He has also delivered several award orations including the Prof. B.K. Bachhawat Memorial Lecture of the National Academy of Sciences, India in 2011[15] and the Platinum Jubilee Lecture at the 102nd edition of the Indian Science Congress in 2015.[16]

Awards and honors

The Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 1998.[7] He received the M. Sreenivasaya Memorial Award of the Society of Biological Chemists (India) in 2005[17] and the J. C. Bose National Fellowship in 2010.[18] The National Academy of Sciences, India elected him as their fellow in 1996 and the Indian Academy of Sciences and the Indian National Science Academy followed suit in 2007 and 2011 respectively.[6]

Selected bibliography
  • Debi P Sarkar; Stephen J Morris; Ofer Eidelman; Joshua Zimmerberg; Robert Blumenthal (July 1989). "Initial stages of influenza hemagglutinin-induced cell fusion monitored simultaneously by two fluorescent events: cytoplasmic continuity and lipid mixing". Journal of Cell Biology. 109 (1): 113–122. CiteSeerX 10.1.1.277.6857. doi:10.1083/jcb.109.1.113.
  • Membrane Fusion Technique. Gulf Professional Publishing. July 1993. pp. 42–. ISBN 978-0-12-182122-7.
  • Robert Blumenthal; Debi P Sarkar; Stewart Durell; Daniel E Howard; Stephen J Morris (October 1996). "Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events". Journal of Cell Biology. 135 (1): 63–71. doi:10.1083/jcb.135.1.63. PMC 2121025.
  • Komal Ramani; Roop S Bora; Mukesh Kumar; Sandeep K Tyagi; Debi P Sarkar (March 1997). "Novel gene delivery to liver cells using engineered virosomes". FEBS Letters. 404 (2–3): 164–168. doi:10.1016/s0014-5793(97)00120-8.
  • Siddhartha S Jana; Dhruba J Bharali; Prashant Mani; Amarnath Maitra; Chhitar M Gupta; Debi P Sarkar (March 2002). "Targeted cytosolic delivery of hydrogel nanoparticles into HepG2 cells through engineered Sendai viral envelopes". FEBS Letters. 515 (1–3): 184–188. doi:10.1016/s0014-5793(02)02467-5.
  • Debi P Sarkar; Komal Ramani; Sandeep K Tyagi (2002). "Targeted Gene Delivery by Virosomes". Liposome Methods and Protocols: 163–173.
  • Indu Kohaar; Showket Hussain; Nisha Thakur; Pratibha Tiwari; Vilas Nasare; Swaraj Batra; Veena Singh; Suresh Bhambani; Bhudev C Das; Debi P Sarkar; Mausumi Bharadwaj (April 2009). "Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women". Human Immunology. 70 (4): 222–229. doi:10.1016/j.humimm.2009.01.003. PMID 19272325.
  • Sunandini Chandra; Raju Kalaivani; Manoj Kumar; Narayanaswamy Srinivasan; Debi P. Sarkar (October 2017). "Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes". Mol. Biol. Cell. 28 (26): 3801–3814. doi:10.1091/mbc.E17-06-0400. PMC 5739296. PMID 29074568.
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See also

Notes
  1. Please see Selected bibliography section

References
  1. D. P. Burma (2011). From Physiology and Chemistry to Biochemistry. Pearson Education India. pp. 184–. ISBN 978-81-317-3220-5.
  2. Ameeta Gupta; Ashish Kumar (1 January 2006). Handbook of Universities. Atlantic Publishers & Dist. pp. 210–. ISBN 978-81-269-0607-9.
  3. "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  4. "Fellow profile - Sarkar". Indian Academy of Sciences. 2016. Retrieved 6 October 2016.
  5. "NASI fellows". National Academy of Sciences, India. 2016. Archived from the original on 16 March 2016. Retrieved 8 October 2016.
  6. "Indian fellow - Sarkar". Indian National Science Academy. 2016. Retrieved 11 October 2016.
  7. "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  8. "University Faculty Details Page" (PDF). University of Delhi. 2016. Retrieved 12 October 2016.
  9. D. P. Burma (2011). From Physiology and Chemistry to Biochemistry. Pearson Education India. pp. 146–. ISBN 978-81-317-3220-5.
  10. "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 34. Archived from the original (PDF) on 4 March 2016. Retrieved 5 October 2016.
  11. D. P. Burma; Maharani Chakravorty (2011). From Physiology and Chemistry to Biochemistry. Pearson Education India. pp. 146–. ISBN 978-81-317-3220-5.
  12. "Patent portfolio" (PDF). Delhi University. 2016. Retrieved 13 October 2016.
  13. "Publications Authored by Debi Sarkar". Author profile. PubFacts. 2016. Retrieved 13 October 2016.
  14. "Distinguished Lecture Series" (PDF). CSRI-CDRI Newsletter. 4 (1): 17. April 2012. Archived from the original (PDF) on 30 July 2016.
  15. "Memorial Lecture Awardees 2011". National Academy of Sciences, India. 2016. Retrieved 13 October 2016.
  16. "The Magic Touch of Biology" (PDF). Indian Science Congress Bulletin: 15 of 35. January 2015.
  17. "M. Sreenivasaya Memorial Award". Society of Biological Chemists (India). 2016. Retrieved 13 October 2016.
  18. "Department of Biochemistry". Delhi University. 2016. Retrieved 13 October 2016.

Further reading
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