Dapagliflozin/saxagliptin/metformin


Dapagliflozin/saxagliptin/metformin, sold under the brand name Qternmet XR among others, is a fixed-dose combination anti-diabetic medication used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.[1][2] It is a combination of dapagliflozin, saxagliptin, and metformin.[1][2] It is taken by mouth.[1][2]

Dapagliflozin/saxagliptin/metformin
Combination of
DapagliflozinSGLT-2 inhibitor
SaxagliptinDPP‑4 inhibitor
MetforminAnti-diabetic biguanide
Clinical data
Trade namesQternmet XR, Qtrilmet
AHFS/Drugs.comProfessional Drug Facts
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
KEGG

The most common side effects include infections of the nose and throat, hypoglycaemia (low blood sugar) when used with a sulphonylurea and effects on the gut such as nausea (feeling sick), vomiting, diarrhoea, abdominal (tummy) pain and loss of appetite.[2]

Dapagliflozin/saxagliptin/metformin was approved for medical use in the United States in May 2019, and in the European Union in November 2019.[3][2][4]

Medical uses

In the United States dapagliflozin/saxagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.[1]

In the European Union it is indicated in adults aged 18 years and older with type 2 diabetes mellitus:

  • to improve glycemic control when metformin with or without sulphonylurea (SU) and either saxagliptin or dapagliflozin does not provide adequate glycemic control.[2]
  • when already being treated with metformin and saxagliptin and dapagliflozin.[2]
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References
  1. "Qternmet XR- dapagliflozin saxagliptin and metformin hydrochloride tablet, film coated". DailyMed. 24 January 2020. Retrieved 14 July 2020.
  2. "Qtrilmet EPAR". European Medicines Agency (EMA). Retrieved 14 July 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  3. "Drug Approval Package: Qternmet XR". U.S. Food and Drug Administration (FDA). 27 January 2020. Retrieved 14 July 2020.
  4. "Qternmet XR approved in the US for the treatment of type-2 diabetes". AstraZeneca (Press release). 3 May 2019. Retrieved 14 July 2020.


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