Vildagliptin/metformin

Vildagliptin/metformin, sold under the brand name Eucreas among others, is a fixed-dose combination anti-diabetic medication for the treatment of type 2 diabetes.[3] It was approved for use in the European Union in November 2007,[4] and the approval was updated in 2008.[5][6][7] It combines 50 mg vildagliptin with either 500, 850, or 1000 mg metformin.[8]

Vildagliptin/metformin
Combination of
VildagliptinDipeptidyl peptidase-4 inhibitor
MetforminBiguanide antihyperglycemic agent
Clinical data
Trade namesEucreas, Galvumet, Zomarist, others
AHFS/Drugs.comUK Drug Information
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only) [1][2]
  • In general: ℞ (Prescription only)
Identifiers
KEGG

The most common side effects include nausea (feeling sick), vomiting, diarrhea, abdominal (tummy) pain and loss of appetite.[4][6][7]

Medical uses

Vildagliptin/metformin is indicated in the treatment of type-2 diabetes mellitus:[4][6][7]

  • it is indicated in the treatment of adults who are unable to achieve sufficient glycaemic control at their maximally tolerated dose of oral metformin alone or who are already treated with the combination of vildagliptin and metformin as separate tablets.[4][6][7]
  • it is indicated in combination with a sulphonylurea (i.e. triple combination therapy) as an adjunct to diet and exercise in patients inadequately controlled with metformin and a sulphonylurea.[4][6][7]
  • it is indicated in triple combination therapy with insulin as an adjunct to diet and exercise to improve glycaemic control in patients when insulin at a stable dose and metformin alone do not provide adequate glycaemic control.[4][6][7]
gollark: It was probably handled via some automated tool TJ09 has which just puts in that stuff around the issue.
gollark: More like micromanagement by someone who believes that they have the right to control fansites too.
gollark: (this is now up on the forums).
gollark: ```Unfortunately, it is unavailable, possibly forever, because (according to an email):Thank you for your request to access the Dragon Cave API from host dc.osmarks.tk. At this time, your request could not be granted, for the following reason: You have, through your own admission on the forums, done the exact thing that got EATW banned from the API.This may be a non-permanent issue; feel free to re-submit your request after correcting any issue(s) listed above.Thanks, T.J. Land presumably due to this my server and computer (yes, I should use a VPS, whatever) can no longer access DC. Whether this is sickness checking, scraping, or using EATW's approximation for optimal view count I know not, but oh well. Due to going against the unwritten rules of DC (yes, this is why I was complaining about ridiculous T&C issues) this hatchery is now nonfunctional. Service may be restored if I actually get some notification about what exactly the problem is and undoing it will not make the whole thing pointless. The text at the bottom is quite funny, though.```
gollark: I could add a T&C stating that it is the hatchery's automatic systems' prerogative to take stuff which is sick out of rotation, but none would care.

References
  1. "Eucreas 50 mg/850 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 10 May 2018. Retrieved 8 June 2020.
  2. "Eucreas 50 mg/1000 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Retrieved 8 June 2020.
  3. Halimi S, Schweizer A, Minic B, Foley J, Dejager S (2008). "Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet". Vascular Health and Risk Management. 4 (3): 481–92. doi:10.2147/vhrm.s2503. PMC 2515409. PMID 18827867.
  4. "Eucreas EPAR". European Medicines Agency (EMA). Retrieved 8 June 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  5. "EU approves Novartis's Eucreas diabetes drug". Reuters. 25 February 2008.
  6. "Icandra EPAR". European Medicines Agency (EMA). Retrieved 8 June 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  7. "Zomarist EPAR". European Medicines Agency (EMA). Retrieved 8 June 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  8. "Galvumet".
  • "Vildagliptin". Drug Information Portal. U.S. National Library of Medicine.
  • "Metformin". Drug Information Portal. U.S. National Library of Medicine.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.