dCTP deaminase (dUMP-forming)
In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30) is an enzyme that catalyzes the chemical reaction
- dCTP + 2 H2O dUMP + diphosphate + NH3
| DCTP deaminase (dUMP-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.4.30 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are dCTP and H2O, whereas its 3 products are dUMP, diphosphate, and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.
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References
- Li H, Xu H, Graham DE, White RH (2003). "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase". J. Biol. Chem. 278 (13): 11100–6. doi:10.1074/jbc.M212460200. PMID 12538648.
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